Genome remodelling in a basal-like breast cancer metastasis and xenograft
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Ding, Li, et al. Genome Remodelling In a Basal-like Breast Cancer Metastasis and Xenograft. 2010. https://doi.org/10.17615/wbrb-p089APA
Ding, L., Ellis, M., Li, S., Larson, D., Chen, K., Wallis, J., Harris, C., Mc Lellan, M., Fulton, R., Fulton, L., Abbott, R., Hoog, J., Dooling, D., Koboldt, D., Schmidt, H., Kalicki, J., Zhang, Q., Chen, L., Lin, L., Wendl, M., Mc Michael, J., Magrini, V., Cook, L., Mc Grath, S., Vickery, T., Appelbaum, E., De Schryver, K., Davies, S., Guintoli, T., Lin, L., Crowder, R., Tao, Y., Snider, J., Smith, S., Dukes, A., Sanderson, G., Pohl, C., Delehaunty, K., Fronick, C., Pape, K., Reed, J., Robinson, J., Hodges, J., Schierding, W., Dees, N., Shen, D., Locke, D., Wiechert, M., Eldred, J., Peck, J., Oberkfell, B., Lolofie, J., Du, F., Hawkins, A., O'laughlin, M., Bernard, K., Cunningham, M., Elliott, G., Mason, M., Thompson, J., Ivanovich, J., Goodfellow, P., Perou, C., Weinstock, G., Aft, R., Watson, M., Ley, T., Wilson, R., & Mardis, E. (2010). Genome remodelling in a basal-like breast cancer metastasis and xenograft. https://doi.org/10.17615/wbrb-p089Chicago
Ding, Li, Matthew Ellis, Shunqiang Li, David E Larson, Ken Chen, John W Wallis, Christopher C Harris et al. 2010. Genome Remodelling In a Basal-Like Breast Cancer Metastasis and Xenograft. https://doi.org/10.17615/wbrb-p089- Creator
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Ding, Li
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Ellis, Matthew
- Other Affiliation: Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Li, Shunqiang
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Larson, David E.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Chen, Ken
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Wallis, John W.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Harris, Christopher C.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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McLellan, Michael D.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Fulton, Robert S.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Fulton, Lucinda L.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Abbott, Rachel M.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Hoog, Jeremy
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Dooling, David J.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Koboldt, Daniel C.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Schmidt, Heather
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Kalicki, Joelle
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Zhang, Qunyuan
- Other Affiliation: Department of Genetics and Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri 63108, USA
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Chen, Lei
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Lin, Ling
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Wendl, Michael C.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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McMichael, Joshua F.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Magrini, Vincent J.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Cook, Lisa
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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McGrath, Sean D.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Vickery, Tammi L.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Appelbaum, Elizabeth
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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DeSchryver, Katherine
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Davies, Sherri
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Guintoli, Therese
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Lin, Li
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Crowder, Robert
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Tao, Yu
- Other Affiliation: Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Snider, Jacqueline E.
- Other Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Smith, Scott M.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Dukes, Adam F.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Sanderson, Gabriel E.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Pohl, Craig S.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Delehaunty, Kim D.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Fronick, Catrina C.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Pape, Kimberley A.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Reed, Jerry S.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Robinson, Jody S.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Hodges, Jennifer S.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Schierding, William
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Dees, Nathan D.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Shen, Dong
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Locke, Devin P.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Wiechert, Madeline E.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Eldred, James M.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Peck, Josh B.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Oberkfell, Benjamin J.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Lolofie, Justin T.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Du, Feiyu
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Hawkins, Amy E.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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O'Laughlin, Michelle D.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Bernard, Kelly E.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Cunningham, Mark
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Elliott, Glendoria
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Mason, Mark D.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Thompson, Dominic M., Jr.
- Other Affiliation: Department of Surgery and the Young Women’s Breast Cancer Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Ivanovich, Jennifer L.
- Other Affiliation: Department of Surgery and the Young Women’s Breast Cancer Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Goodfellow, Paul J.
- Other Affiliation: Department of Surgery and the Young Women’s Breast Cancer Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Perou, Charles
- ORCID: https://orcid.org/0000-0001-9827-2247
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Genetics
- Other Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Weinstock, George M.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Aft, Rebecca
- Other Affiliation: Department of Surgery and the Young Women’s Breast Cancer Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Watson, Mark
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Genetics
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Ley, Timothy J.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Wilson, Richard K.
- Other Affiliation: The Genome Center at Washington University, Washington University School of Medicine, St Louis, Missouri 63108, USA
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Mardis, Elaine R.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
- Abstract
- Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples from an African-American patient with basal-like breast cancer: peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The metastasis contained two de novo mutations and a large deletion not present in the primary tumour, and was significantly enriched for 20 shared mutations. The xenograft retained all primary tumour mutations and displayed a mutation enrichment pattern that resembled the metastasis. Two overlapping large deletions, encompassing CTNNA1, were present in all three tumour samples. The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour.
- Date of publication
- 2010
- Keyword
- DOI
- Identifier
- https://doi.org/10.1038/nature08989
- 2-s2.0-77951139631
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Nature
- Journal volume
- 464
- Journal issue
- 7291
- Page start
- 999
- Page end
- 1005
- Language
- English
- Version
- Postprint
- ISSN
- 1476-4687
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- Parents:
This work has no parents.
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