Unmasking of Partial Diabetes Insipidus during Stress but Not Maintenance Dosing of Glucocorticoids in an Infant with Septo-Optic Dysplasia

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Creator
  • Puri, Mala
    • Affiliation: School of Medicine, Department of Pediatrics
  • Azam, Anita
    • Affiliation: School of Medicine, Department of Pediatrics
  • Loechner, Karen J
    • Affiliation: School of Medicine, Department of Pediatrics
Abstract
  • Abstract Background. It is well acknowledged that glucocorticoid (GC) replacement can unmask diabetes insipidus (DI) in subjects with hypopituitarism. Objective. To increase the awareness and monitoring for transient and symptomatic DI in children with partial hypopituitarism during periods in which increased GC needs are required. Methods/Case. A 2-month-old female infant with septo-optic dysplasia (SOD; on thyroid and maintenance GC replacement therapy at 8 mg/m2/day) developed transient DI during 2 separate episodes of stress (one hypothermia, one febrile) when stress dosing of GC (25 mg/m2/day) was instituted. Conclusion. Children not diagnosed with DI during initial evaluation for hypopituitarism may benefit from rescreening of serum sodium levels during acute periods of stress that demand "stress" GC dosing. This will permit treatment and/or increased vigilance for ensuing permanent DI.
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Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Mala Puri et al.; licensee BioMed Central Ltd.
Journal title
  • International Journal of Pediatric Endocrinology
Journal volume
  • 2011
Journal issue
  • 1
Page start
  • 817954
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1687-9856
Bibliographic citation
  • International Journal of Pediatric Endocrinology. 2011 Mar 16;2011(1):817954
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • March 18, 2016

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