Collections > Electronic Theses and Dissertations > Biomarkers of Lung Epithelial Damage After Inhalation Injury

Burn and inhalation injury affects almost half a million people in the United States each year and it is one of the most complicated forms of trauma to treat. Further research is needed in order to better understand the precise mechanisms behind both burn and inhalational injury, as well as means by which to more accurately stratify patients by injury severity in order to care for them more effectively. In this study, I examine two potential biomarkers in mice with possible translational relevance that could be of use in quantifying injury severity in hospitalized patients. IL-33 and 8-isoprostane may be indicators of acute and long-term damage, respectively. IL-33 is elevated at twenty-four hours post-injury in mice with inhalation injury, while 8-isoprostane is elevated in mice with combined burn + inhalation injury at two weeks post-injury. These data may begin to provide a method for better patient evaluation and improved outcome.