Next generation nitric oxide-releasing polyurethane membranes for implantable glucose biosensors
Public Deposited- Last Modified
- February 26, 2019
- Creator
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Wang, Xingzhi
- Affiliation: College of Arts and Sciences, Department of Chemistry
- Abstract
- Herein, fabrication of polyurethane glucose sensor membranes doped with next generation biocompatible macromolecular nitric oxide-releasing scaffolds (hyperbranched polyesters, hyperbranched polyurethanes, alginate) was reported. Nitric oxide-releasing S-nitrosothiol-modified hyperbranched polyesters-doped membranes achieved extended nitric oxide-release (> 48 h) and promising in vitro sensor performance (sensitivity 20.9 nA/mM, linear dynamic range 0 – 15 mM). Nitric oxide-releasing N-diazeniumdiolate-modified hyperbranched polyurethanes-doped membranes showed desirable smooth membrane morphology, but had relatively limited nitric oxide-releasing duration (up to 18 h) and half-life (~ 0.4 h). Nitric oxide-releasing N-diazeniumdiolate-modified alginate-doped membranes showed significantly longer nitric oxide-releasing half-life (~ 1.2 h) with hyperbranched polyurethanes, but their nitric oxide-releasing duration (< 20 h) was still limited. Challenges for future studies on this subject lie in extending the nitric oxide-releasing lifetimes of the membranes and obtaining more control over the nitric oxide-release kinetics.
- Date of publication
- April 2018
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: Summer undergraduate research fellowship
- Advisor
- Schoenfisch, Mark H.
- Degree
- Bachelor of Science
- Academic concentration
- Chemistry
- Honors level
- Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 2018
- Language
- English
Relations
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