Common genetic variation near MC4R is associated with waist circumference and insulin resistance

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  • Chambers, John C.
    • Other Affiliation: Department of Epidemiology and Public Health, Imperial College London
  • Elliott, Paul
    • Other Affiliation: Department of Epidemiology and Public Health, Imperial College London
  • Zabaneh, Delilah
    • Other Affiliation: Department of Epidemiology and Public Health, Imperial College London
  • Zhang, Weihua
    • Other Affiliation: Department of Epidemiology and Public Health, Imperial College London
  • Li, Yun
    • Other Affiliation: Center for Statistical Genetics, University of Michigan
  • Froguel, Philippe
    • Other Affiliation: Section of Genomic Medicine, Imperial College London, Hammersmith Hospital
  • Balding, David
    • Other Affiliation: Department of Epidemiology and Public Health, Imperial College London
  • Scott, James
    • Other Affiliation: National Heart and Lung Institute, Imperial College London Hammersmith Hospital
  • Kooner, Jaspal S.
    • Other Affiliation: National Heart and Lung Institute, Imperial College London Hammersmith Hospital
Abstract
  • We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 × 10−9) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have ∼2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.
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  • Article
Rights statement
  • In Copyright
Journal title
  • Nature Genetics
Journal volume
  • 40
Journal issue
  • 6
Page start
  • 716
Page end
  • 718
Language
  • English
Version
  • Postprint
ISSN
  • 1061-4036

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