Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form
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Lin, Fang Ju, et al. Measuring Health-related Quality of Life In Chronic Obstructive Pulmonary Disease: Properties of the Eq-5d-5l and Promis-43 Short Form. BioMed Central Ltd, 2014. https://doi.org/10.17615/m0mp-7b36APA
Lin, F., Pickard, A., Krishnan, J., Joo, M., Au, D., Carson, S., Gillespie, S., Henderson, A., Lindenauer, P., Mc Burnie, M., Mularski, R., Naureckas, E., Vollmer, W., & Lee, T. (2014). Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form. BioMed Central Ltd. https://doi.org/10.17615/m0mp-7b36Chicago
Lin, Fang Ju, A Pickard, Jerry A Krishnan, Min J Joo, David H Au, Shannon Carson, Suzanne Gillespie et al. 2014. Measuring Health-Related Quality of Life In Chronic Obstructive Pulmonary Disease: Properties of the Eq-5d-5l and Promis-43 Short Form. BioMed Central Ltd. https://doi.org/10.17615/m0mp-7b36- Creator
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Lin, Fang-Ju
- Other Affiliation: University of Illinois at Chicago, Chicago, IL, USA
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Pickard, A
- Other Affiliation: Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St., M/C 886, Chicago, IL 60612, USA
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Krishnan, Jerry A
- Other Affiliation: University of Illinois at Chicago, Chicago, IL, USA; University of Illinois Hospital & Health Sciences System, Chicago, IL, USA
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Joo, Min J
- Other Affiliation: University of Illinois Hospital & Health Sciences System, Chicago, IL, USA
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Au, David H
- Other Affiliation: VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA
- Carson, Shannon
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Gillespie, Suzanne
- Other Affiliation: Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA
- Henderson, Ashley
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Lindenauer, Peter K
- Other Affiliation: Baystate Medical Center, Springfield, MA, USA; Tufts University School of Medicine, Boston, MA, USA
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McBurnie, Mary
- Other Affiliation: Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA
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Mularski, Richard A
- Other Affiliation: Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA
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Naureckas, Edward T
- Other Affiliation: University of Chicago, Chicago, IL, USA
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Vollmer, William M
- Other Affiliation: Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA
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Lee, Todd A
- Other Affiliation: University of Illinois at Chicago, Chicago, IL, USA
- Abstract
- Abstract Background The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that have potentially broad application in evaluating treatments and capturing burden of respiratory-related diseases. The aims of this study were: (1) to examine their psychometric properties in patients with chronic obstructive pulmonary disease (COPD), and (2) to identify dimensions of HRQL that differ and do not differ by lung function. Methods We conducted a multi-center, cross-sectional study (“COPD Outcomes-based Network for Clinical Effectiveness & Research Translation” [CONCERT]). We analyzed patients who met spirometric criteria for COPD, and completed EQ-5D-5L and PROMIS questionnaires. Disease severity was graded based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. Pulmonary function test, PROMIS-43, EQ-5D (index score and EQ-Visual Analog Scale [EQ-VAS]), six minute walk test (6MWT), and three dyspnea scales (mMRC, Borg, FACIT-Dyspnea) were administered. Validity and reliability of EQ-5D-5L and PROMIS-43 were examined, and differences in HRQL by GOLD grade were assessed. Results Data from 670 patients with COPD were analyzed (mean age 68.5 years; 58% male). More severe COPD was associated with more problems with mobility, self-care and usual activities (all p-values <0.01) according to EQ-5D-5L. Related domains on EQ-5D-5L, PROMIS and clinical measures were moderately (r = 0.30-0.49) to strongly (r ≥ 0.50) correlated. A statistically significant trend of decreasing HRQL with more severe lung functions was observed for EQ-5D-5L index scores, EQ-VAS scores, and PROMIS physical function and social roles. Conclusions Results supported the validity of EQ-5D-5L and PROMIS-43 in COPD patients, and indicate that physical function and social activities decrease with level of lung function by GOLD grade, but not pain, mental health, sleep or fatigue as reported by patients.
- Date of publication
- June 16, 2014
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Fang-Ju Lin et al.; licensee BioMed Central Ltd.
- License
- Journal title
- BMC Medical Research Methodology
- Journal volume
- 14
- Journal issue
- 1
- Page start
- 78
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1471-2288
- Bibliographic citation
- BMC Medical Research Methodology. 2014 Jun 16;14(1):78
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- July 15, 2016
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