Enhanced cavitation enables DNA and chromatin extraction from archived tissues
Public Deposited- Last Modified
- February 26, 2019
- Creator
-
Quimby, Austin
- Affiliation: College of Arts and Sciences, Department of Biology
- Abstract
- The term “epigenetics” refers to heritable changes in gene expression not associated with alteration of DNA sequence. There is considerable research exploring how changes at the epigenetic level influence tumor progression. Preservation of tissue samples with the formalin fixed, paraffin embedded (FFPE) technique is commonly used to archive tumor biopsy samples. There is currently no method for extracting chromatin from FFPE tissue that is compatible with all downstream analysis techniques.
- Date of publication
- spring 2016
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: Sarah Steele Danhoff Undergraduate Research Fund
- Advisor
- Pattenden, Samantha
- Degree
- Bachelor of Science
- Honors level
- Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 17
Relations
- Parents:
This work has no parents.