Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
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Cheang, Maggie C.U, et al. Basal-like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value Than Triple-negative Phenotype. 2008. https://doi.org/10.17615/9nr0-8t30APA
Cheang, M., Voduc, D., Bajdik, C., Leung, S., Mc Kinney, S., Chia, S., Perou, C., & Nielsen, T. (2008). Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. https://doi.org/10.17615/9nr0-8t30Chicago
Cheang, Maggie C.U., David Voduc, Chris Bajdik, Samuel Leung, Steven Mc Kinney, Stephen K Chia, Charles Perou et al. 2008. Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value Than Triple-Negative Phenotype. https://doi.org/10.17615/9nr0-8t30- Creator
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Cheang, Maggie C.U.
- Other Affiliation: Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia
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Voduc, David
- Other Affiliation: Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia; BC Cancer Agency, Vancouver, British Columbia, Canada
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Bajdik, Chris
- Other Affiliation: Cancer Control Research Program, BC Cancer Agency
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Leung, Samuel
- Other Affiliation: Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia
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McKinney, Steven
- Other Affiliation: Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia
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Chia, Stephen K.
- Other Affiliation: BC Cancer Agency, Vancouver, British Columbia, Canada
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Perou, Charles
- ORCID: https://orcid.org/0000-0001-9827-2247
- Affiliation: School of Medicine, Department of Genetics
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Nielsen, Torsten O.
- Other Affiliation: Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia
- Abstract
- Purpose: Basal-like breast cancer is associated with high grade, poor prognosis, and younger patient age. Clinically, a triple-negative phenotype definition [estrogen receptor, progesterone receptor, and human epidermal growth factor receptor (HER)-2, all negative] is commonly used to identify such cases. EGFR and cytokeratin 5/6 are readily available positive markers of basallike breast cancer applicable to standard pathology specimens. This study directly compares the prognostic significance between three- and five-biomarker surrogate panels to define intrinsic breast cancer subtypes, using a large clinically annotated series of breast tumors. Experimental Design: Four thousand forty-six invasive breast cancers were assembledinto tissuemicroarrays. Allhad staging, pathology, treatment, andoutcomeinformation;median follow-up was12.5 years. Cox regression analyses and likelihood ratio tests compared the prognostic significance for breast cancer death-specific survival (BCSS) of the twoimmunohistochemicalpanels. Results: Among3,744interpretable cases,17%werebasalusing the triple-negativedefinition(10- year BCSS, 6 7%) and 9% were basal using the five-marker method (10-year BCSS, 62%). Likelihood ratio tests ofmultivariable Coxmodelsincluding standard clinical variables show that the fivemarker panel is significantly more prognostic than the three-marker panel.The poor prognosis of triple-negative phenotype is conferred almost entirely by those tumors positive for basal markers. Among triple-negativepatients treatedwithadjuvant anthracycline-based chemotherapy, theadditionalpositive basalmarkersidentified a cohort of patients with significantly worse outcome. Conclusions:The expanded surrogate immunopanel of estrogen receptor, progesterone receptor, human HER-2, EGFR, and cytokeratin 5/6 provides a more specific definition of basal-like breast cancer that better predicts breast cancer survival.
- Date of publication
- 2008
- DOI
- Identifier
- 2-s2.0-40949121882
- https://doi.org/10.1158/1078-0432.CCR-07-1658
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Clinical Cancer Research
- Journal volume
- 14
- Journal issue
- 5
- Page start
- 1368
- Page end
- 1376
- Language
- English
- Version
- Postprint
- ISSN
- 1078-0432
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