Language delay aggregates in toddler siblings of children with autism spectrum disorder
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Marrus, N, et al. Language Delay Aggregates In Toddler Siblings of Children with Autism Spectrum Disorder. BioMed Central, 2018. https://doi.org/10.17615/wkh9-w091APA
Marrus, N., Hall, L., Paterson, S., Elison, J., Wolff, J., Swanson, M., Parish Morris, J., Eggebrecht, A., Pruett, J., Hazlett, H., Zwaigenbaum, L., Dager, S., Estes, A., Schultz, R., Botteron, K., Piven, J., & Constantino, J. (2018). Language delay aggregates in toddler siblings of children with autism spectrum disorder. BioMed Central. https://doi.org/10.17615/wkh9-w091Chicago
Marrus, N, L P Hall, S J Paterson, J T Elison, J J Wolff, M R Swanson, J Parish Morris et al. 2018. Language Delay Aggregates In Toddler Siblings of Children with Autism Spectrum Disorder. BioMed Central. https://doi.org/10.17615/wkh9-w091- Creator
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Marrus, N
- Other Affiliation: Washington University School of Medicine
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Hall, L P
- Other Affiliation: St. Jude Children’s Research Hospital
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Paterson, S J
- Other Affiliation: Temple University
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Elison, J T
- Other Affiliation: University of Minnesota
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Wolff, J J
- Other Affiliation: University of Minnesota
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Swanson, M R
- Affiliation: School of Medicine, Department of Psychiatry
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Parish-Morris, J
- Other Affiliation: University of Pennsylvania
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Eggebrecht, A T
- Other Affiliation: Washington University School of Medicine
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Pruett, J R
- Other Affiliation: Washington University School of Medicine
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Hazlett, H C
- Affiliation: School of Medicine, Department of Psychiatry
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Zwaigenbaum, L
- Other Affiliation: University of Alberta
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Dager, S
- Other Affiliation: University of Washington
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Estes, A M
- Other Affiliation: University of Washington
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Schultz, R T
- Other Affiliation: University of Pennsylvania
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Botteron, K N
- Other Affiliation: Washington University School of Medicine
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Piven, J
- Affiliation: School of Medicine, Department of Psychiatry
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Constantino, J N
- Other Affiliation: Washington University School of Medicine
- Abstract
- Background Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype. Methods We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique samples; an advantage of the latter was its sensitivity in quantifying early manifestations of language delay while accounting for covariates within a single large sample. Results Meta-analysis showed that high-risk siblings without ASD (HR-noASD) were three to four times more likely to exhibit language delay versus low-risk siblings without ASD (LR-noASD) and had lower mean receptive and expressive language scores. Analyses of IBIS data corroborated that language delay, specifically receptive language delay, was more frequent in the HR-noASD (n = 235) versus LR-noASD group (n = 115). IBIS language scores were continuously and unimodally distributed, with a pathological shift towards decreased language function in HR-noASD siblings. The elevated inherited risk for ASD was associated with lower receptive and expressive language scores when controlling for sociodemographic factors. For receptive but not expressive language, the effect of risk group remained significant even when controlling for nonverbal cognition. Conclusions Greater frequency of language delay and a lower distribution of language scores in high-risk, unaffected toddler-aged siblings support decreased early language ability as an endophenotype for ASD, with a more pronounced effect for receptive versus expressive language. Further characterization of language development is warranted to refine genetic investigations of ASD and to elucidate factors influencing the progression of core autistic traits and related symptoms.
- Date of publication
- October 22, 2018
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- The Author(s).
- Journal title
- Journal of Neurodevelopmental Disorders
- Journal volume
- 10
- Journal issue
- 1
- Page start
- 29
- Language
- English
- Bibliographic citation
- Journal of Neurodevelopmental Disorders. 2018 Oct 22;10(1):29
- Publisher
- BioMed Central
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