Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

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  • Baldwin, Albert
  • Bassères, D.S.
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
Abstract
  • Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB) signaling pathway in controlling the initiation and progression of human cancer. NF-κB and associated regulatory proteins such as IκB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-κB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-κB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-κB. Additionally, the effects of NF-κB activation in tumors relative to cancer therapy are also discussed.
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  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Oncogene
Journal volume
  • 25
Journal issue
  • 51
Page start
  • 6817
Page end
  • 6830
Language
  • English
Version
  • Postprint
ISSN
  • 1476-5594

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