Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study
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Dromain, Clarisse, et al. Dual-energy Contrast-enhanced Digital Mammography: Initial Clinical Results of a Multireader, Multicase Study. BioMed Central, 2012. https://doi.org/10.17615/qn9y-1w57APA
Dromain, C., Thibault, F., Diekmann, F., Fallenberg, E., Jong, R., Koomen, M., Hendrick, R., Tardivon, A., & Toledano, A. (2012). Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study. BioMed Central. https://doi.org/10.17615/qn9y-1w57Chicago
Dromain, Clarisse, Fabienne Thibault, Felix Diekmann, Eva M Fallenberg, Roberta A Jong, Marcia Koomen, R E Hendrick et al. 2012. Dual-Energy Contrast-Enhanced Digital Mammography: Initial Clinical Results of a Multireader, Multicase Study. BioMed Central. https://doi.org/10.17615/qn9y-1w57- Creator
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Dromain, Clarisse
- Other Affiliation: Department of Radiology, Institut de cancérologie Gustave-Roussy, 39 rue Camille Desmoulin, Villejuif, 94805 France
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Thibault, Fabienne
- Other Affiliation: Department of Radiology, Institut Curie, 26 rue d’Ulm, Paris, 75005, France
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Diekmann, Felix
- Other Affiliation: Department of Radiology, University Hospital Charite, 1 charitéplatz, D - 10117 Berlin, Germany
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Fallenberg, Eva M
- Other Affiliation: Department of Radiology, University Hospital Charite, 1 charitéplatz, D - 10117 Berlin, Germany
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Jong, Roberta A
- Other Affiliation: Department of Medical Imaging, Sunnybrook and Women’s College Health Sciences Center, 2075 Bayview Avenue, MG178 Toronto, ON, Canada M4N 3M5
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Koomen, Marcia
- Affiliation: School of Medicine, Department of Radiology
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Hendrick, R E
- Other Affiliation: Department of Radiology, University of Colorado, Denver, Aurora, CO 80045, USA
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Tardivon, Anne
- Other Affiliation: Department of Radiology, Institut Curie, 26 rue d’Ulm, Paris, 75005, France
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Toledano, Alicia
- Other Affiliation: Statistic, Statistics Collaborative, 1625 Massachusetts Avenue, NW, Suite 600, Washington, DC 20036, USA
- Abstract
- Abstract Introduction The purpose of this study was to compare the diagnostic accuracy of dual-energy contrast-enhanced digital mammography (CEDM) as an adjunct to mammography (MX) ± ultrasonography (US) with the diagnostic accuracy of MX ± US alone. Methods One hundred ten consenting women with 148 breast lesions (84 malignant, 64 benign) underwent two-view dual-energy CEDM in addition to MX and US using a specially modified digital mammography system (Senographe DS, GE Healthcare). Reference standard was histology for 138 lesions and follow-up for 12 lesions. Six radiologists from 4 institutions interpreted the images using high-resolution softcopy workstations. Confidence of presence (5-point scale), probability of cancer (7-point scale), and BI-RADS scores were evaluated for each finding. Sensitivity, specificity and ROC curve areas were estimated for each reader and overall. Visibility of findings on MX ± CEDM and MX ± US was evaluated with a Likert scale. Results The average per-lesion sensitivity across all readers was significantly higher for MX ± US ± CEDM than for MX ± US (0.78 vs. 0.71 using BIRADS, p = 0.006). All readers improved their clinical performance and the average area under the ROC curve was significantly superior for MX ± US ± CEDM than for MX ± US ((0.87 vs 0.83, p = 0.045). Finding visibility was similar or better on MX ± CEDM than MX ± US in 80% of cases. Conclusions Dual-energy contrast-enhanced digital mammography as an adjunct to MX ± US improves diagnostic accuracy compared to MX ± US alone. Addition of iodinated contrast agent to MX facilitates the visualization of breast lesions.
- Date of publication
- June 14, 2012
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Dromain et al.; licensee BioMed Central Ltd.
- Language
- English
- Bibliographic citation
- Breast Cancer Research. 2012 Jun 14;14(3):R94
- Publisher
- BioMed Central
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