The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae

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  • Gross, Roy
    • Other Affiliation: Chair of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany
  • Guzman, Carlos A
    • Other Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Sebaihia, Mohammed
    • Other Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
  • Martins dos Santos, Vítor AP
    • Other Affiliation: Division of Molecular Biotechnology, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Pieper, Dietmar H
    • Other Affiliation: Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Koebnik, Ralf
    • Other Affiliation: Institut de Recherche pour le Développement UMR 5096, CNRS-UP-IRD 911, Avenue Agropolis, BP 64501, 34394 Montpellier, Cedex 5, France
  • Lechner, Melanie
    • Other Affiliation: Chair of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany
  • Bartels, Daniela
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany; Mathematics and Computer Science Division, Argonne National Laboratory, USA
  • Buhrmester, Jens
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany; Roche Diagnostics GmbH, Nonnenwald 2, D-82377 Penzberg, Germany
  • Choudhuri, Jomuna V
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany; BASF Plant Science GmbH, D-67117 Limburgerhof, Germany
  • Ebensen, Thomas
    • Other Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Gaigalat, Lars
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany
  • Herrmann, Stefanie
    • Other Affiliation: Institute for Microbiology and Hygiene, Charité Berlin, Dorotheen-Str. 96, D-10117 Berlin, Germany
  • Khachane, Amit N
    • Other Affiliation: Division of Molecular Biotechnology, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Larisch, Christof
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany
  • Link, Stefanie
    • Other Affiliation: Chair of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany
  • Linke, Burkhard
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany
  • Meyer, Folker
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany; Mathematics and Computer Science Division, Argonne National Laboratory, USA
  • Mormann, Sascha
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany
  • Nakunst, Diana
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany
  • Rückert, Christian
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany
  • Schneiker-Bekel, Susanne
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany
  • Schulze, Kai
    • Other Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Vorhölter, Frank-Jörg
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany
  • Yevsa, Tetyana
    • Other Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Engle, Jacquelyn T
    • Other Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • Goldman, William
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
  • Pühler, Alfred
    • Other Affiliation: Chair of Genetics, Bielefeld University, D-33501 Bielefeld, Germany
  • Göbel, Ulf B
    • Other Affiliation: Institute for Microbiology and Hygiene, Charité Berlin, Dorotheen-Str. 96, D-10117 Berlin, Germany
  • Goesmann, Alexander
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany
  • Blöcker, Helmut
    • Other Affiliation: Department of Genome Analysis, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
  • Kaiser, Olaf
    • Other Affiliation: Center for Biotechnology (CeBiTec), Bielefeld University, D-33501 Bielefeld, Germany; Roche Diagnostics GmbH, Nonnenwald 2, D-82377 Penzberg, Germany
  • Martinez-Arias, Rosa
    • Other Affiliation: Department of Genome Analysis, Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
Abstract
  • Abstract Background Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. Results In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. Conclusion The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.
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  • Article
Rights statement
  • In Copyright
Rights holder
  • Roy Gross et al.; licensee BioMed Central Ltd.
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Journal title
  • BMC Genomics
Journal volume
  • 9
Journal issue
  • 1
Page start
  • 449
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-2164
Bibliographic citation
  • BMC Genomics. 2008 Sep 30;9(1):449
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • January 15, 2016

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