The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

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  • Zhang, Hong-Yun
    • Other Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
  • Fei, Man-Dong
    • Other Affiliation: Centre for Disease Control and Prevention of Yunnan Province, China
  • Jiang, Yong
    • Other Affiliation: Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China
  • Fei, Qiu-Yue
    • Other Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
  • Qian, Hong
    • Other Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
  • Xu, Lin
    • Other Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
  • Jin, Yu-Ni
    • Other Affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
  • Jiang, Cheng-Qin
    • Other Affiliation: Women and Children’s Hospital of Luxi County, Luxi, China
  • Li, Hai-Xia
    • Other Affiliation: Women and Children’s Hospital of Luxi County, Luxi, China
  • Tiggelaar, Sarah M
    • Other Affiliation: Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China; Vanderbilt University, Nashville, USA
  • Smith, Jennifer
  • Sahasrabuddhe, Vikrant V
    • Other Affiliation: Vanderbilt University, Nashville, USA
  • Qiao, You-Lin
    • Other Affiliation: Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Abstract
  • Abstract Background Yunnan has one of the oldest and the most severe human immunodeficiency virus (HIV) epidemics in China. We conducted an observational study to evaluate the human papillomavirus (HPV) genotype distribution in relation to cervical neoplastic disease risk among HIV-infected women in Yunnan. Methods We screened 301 HIV-infected non-pregnant women in Mangshi prefecture in Yunnan province. All consenting participants underwent simultaneous and independent assessment by cervical cytology, colposcopy-histopathology, and HPV genotyping. Unadjusted and multivariable-adjusted multinomial logistic regression analysis was conducted to evaluate factors associated with single or multiple carcinogenic HPV genotypes. Results HPV genotypes were present in 43.5% (131/301) overall, and carcinogenic HPV genotypes were present in 37.5% (113/301) women. Among women with carcinogenic HPV genotypes, 80 (70.8% of 113) had a single carcinogenic HPV type, while 33 (29.2%) women had multiple (2 or more) carcinogenic HPV types. Overall, the most common carcinogenic HPV types were HPV52 (7.3%), HPV58 (6.6%), HPV18 (6.3%), HPV16 (6.0%), and HPV33 (5.3%). In women with cervical precancerous lesions (i.e., high-grade squamous intraepithelial lesions [HSIL] on cytology or cervical intraepithelial neoplasia grade 2 or worse [CIN2+] detected on colposcopy-histology), the most commonly detected genotypes were HPV16 (28.6%), HPV52 (25.0%), HPV58 (17.9%), HPV18 (10.7%) and HPV31 (10.7%). Increasing age was an independent risk factor associated with presence of single carcinogenic HPV types (adjusted odds ratio: 1.04, 95%CI: 1.01-1.07, p = 0.012) but not with the presence of multiple carcinogenic types in the multivariable-adjusted models. Conclusions As HIV-infected women continue to live longer on antiretroviral therapy in China, it will be increasingly important to screen for, and prevent, HPV-associated cervical cancer in this population, especially given the wide diversity and multiplicity of HPV genotypes.
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  • Article
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  • In Copyright
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  • Zhang et al.; licensee BioMed Central.
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  • English
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  • Virology Journal. 2014 Dec 07;11(1):202
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  • BioMed Central

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