DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years

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  • Gonzalez-Nahm, Sarah
    • Other Affiliation: Johns Hopkins Bloomberg School of Public Health
  • Mendez, Michelle A
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
  • Benjamin-Neelon, Sara E
    • Other Affiliation: Johns Hopkins Bloomberg School of Public Health
  • Murphy, Susan K
    • Other Affiliation: Duke University Medical Center
  • Hogan, Vijaya K
    • Other Affiliation: W.K. Kellogg Foundation
  • Rowley, Diane L
    • Affiliation: Gillings School of Global Public Health, Department of Maternal and Child Health
  • Hoyo, Cathrine
    • Other Affiliation: North Carolina State University
Abstract
  • Background This study assessed the associations between nine differentially methylated regions (DMRs) of imprinted genes in DNA derived from umbilical cord blood leukocytes in males and females and (1) birth weight for gestational age z score, (2) weight-for-length (WFL) z score at 1 year, and (3) body mass index (BMI) z score at 3 years. Methods We conducted multiple linear regression in n = 567 infants at birth, n = 288 children at 1 year, and n = 294 children at 3 years from the Newborn Epigenetics Study (NEST). We stratified by sex and adjusted for race/ethnicity, maternal education, maternal pre-pregnancy BMI, prenatal smoking, maternal age, gestational age, and paternal race. We also conducted analysis restricting to infants not born small for gestational age. Results We found an association between higher methylation of the sequences regulating paternally expressed gene 10 (PEG10) and anthropometric z scores at 1 year (β = 0.84; 95% CI = 0.34, 1.33; p = 0.001) and 3 years (β = 1.03; 95% CI = 0.37, 1.69; p value = 0.003) in males only. Higher methylation of the DMR regulating mesoderm-specific transcript (MEST) was associated with lower anthropometric z scores in females at 1 year (β = − 1.03; 95% CI − 1.60, − 0.45; p value = 0.001) and 3 years (β = − 1.11; 95% CI − 1.98, − 0.24; p value = 0.01). These associations persisted when we restricted to infants not born small for gestational age. Conclusion Our data support a sex-specific association between altered methylation and weight status in early life. These methylation marks can contribute to the compendium of epigenetically regulated regions detectable at birth, influencing obesity in childhood. Larger studies are required to confirm these findings.
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  • Article
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  • In Copyright
Rights holder
  • The Author(s).
Journal title
  • Clinical Epigenetics
Journal volume
  • 10
Journal issue
  • 1
Page start
  • 90
Language
  • English
Bibliographic citation
  • Clinical Epigenetics. 2018 Jun 28;10(1):90
Publisher
  • BioMed Central

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