The Functional Connectivity of the Resting Brain in Children With Attention Deficit Hyperactivity Disorder
Public Deposited- Last Modified
- February 26, 2019
- Creator
-
Guerra, Carina
- Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
- Abstract
- Attention deficit hyperactivity disorder (ADHD) is a prevalent and detrimental psychiatric disorder that is recently being examined with a distributed network perspective using functional magnetic resonance imaging (fMRI). Specific disruptions in the connections within and in between intrinsic connectivity networks during a resting state have been considered as a way to characterize various psychiatric disorders including ADHD. Disruptions in the within-network connectivity of the default mode network (DMN) as well as in the regulation of the salience network (SAL) have been implicated in the pathophysiology of ADHD. The current study examined these disruptions by performing independent component analyses on the resting state fMRI scans of 13 children with ADHD and 13 age and gender matched neurotypical children. SAL activations were compared between groups to determine whether the SAL was being adequately attenuated in children with ADHD. Our results indicate that the left prefrontal cortical region of the SAL was improperly attenuated, while the left posterior parietal region was overly attenuated during a resting state in children with ADHD compared to controls. Intrinsic connectivity of the DMN was examined using group correlation matrices. Results from this analysis show that some of the connectivities within the DMN exhibited previously determined developmentally delayed trends that highlighted a failure for circuitry to integrate. However, several other connectivities found to be disrupted in the current study in children with ADHD were not connectivities that had been identified by previous literature to be developmentally dynamic. Therefore, these findings provide mixed results that do not unanimously support the maturational delay hypothesis of ADHD. Overall, this study’s findings provide preliminary evidence that state-inappropriate SAL activations and specific connectivity disruptions within the DMN are present during the resting state in children with ADHD.
- Date of publication
- spring 2018
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Belger, Aysenil
- Degree
- Bachelor of Science
- Academic concentration
- Psychology
- Honors level
- Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 2018
- Language
- English
Relations
- Parents:
This work has no parents.
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
2018_Guerra.pdf | 2019-05-18 | Public | Download |