Firefighters display sub-standard fitness despite strenuous occupational duties, and are at risk for cardiovascular disease (CVD). Muscular strength may provide a protect effect, independent of cardiorespiratory fitness (CRF). The purpose of the present study was to examine the relationship between CVD risk factor profiles and isokinetic muscular strength in overweight firefighters, prior to and after accounting for CRF. A CVD risk factor profile was created using blood pressure, blood lipids, and body fat, while peak torque (PT) was measured during a slow (60°/sec) and fast (240°/sec) isokinetic muscle action of the leg extensors in 43 overweight and obese (BMI>25) career firefighters. No relationship was found between CVD risk factor profiles and slow (r=-0.10, P=0.51) or fast (r=-0.14, P=0.37) isokinetic PT, even when accounting for CRF (P>0.05). These finding suggest there is no protective effect of muscular strength from CVD risk factors in this sample of overweight and obese firefighters.