Reproductive aging associated common genetic variants and the risk of breast cancer
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He, Chunyan, et al. Reproductive Aging Associated Common Genetic Variants and the Risk of Breast Cancer. BioMed Central Ltd, 2012. https://doi.org/10.17615/wf1w-wv20APA
He, C., Chasman, D., Dreyfus, J., Hwang, S., Ruiter, R., Sanna, S., Buring, J., Fernández Rhodes, L., Franceschini, N., Hankinson, S., Hofman, A., Lunetta, K., Palmieri, G., Porcu, E., Rivadeneira, F., Rose, L., Splansky, G., Stolk, L., Uitterlinden, A., Chanock, S., Crisponi, L., Demerath, E., Murabito, J., Ridker, P., Stricker, B., & Hunter, D. (2012). Reproductive aging associated common genetic variants and the risk of breast cancer. BioMed Central Ltd. https://doi.org/10.17615/wf1w-wv20Chicago
He, Chunyan, Daniel I Chasman, Jill Dreyfus, Shih Jen Hwang, Rikje Ruiter, Serena Sanna, Julie E Buring et al. 2012. Reproductive Aging Associated Common Genetic Variants and the Risk of Breast Cancer. BioMed Central Ltd. https://doi.org/10.17615/wf1w-wv20- Creator
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He, Chunyan
- Other Affiliation: Department of Public Health, Indiana University School of Medicine
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Chasman, Daniel I
- Other Affiliation: Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School
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Dreyfus, Jill
- Other Affiliation: Division of Epidemiology and Community Health, University of Minnesota
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Hwang, Shih-Jen
- Other Affiliation: Framingham Heart Study, The National Heart Lung and Blood Institute
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Ruiter, Rikje
- Other Affiliation: Department of Epidemiology, Erasmus Medical Center
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Sanna, Serena
- Other Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche
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Buring, Julie E
- Other Affiliation: Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School
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Fernández-Rhodes, Lindsay
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Franceschini, Nora
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Hankinson, Susan E
- Other Affiliation: Department of Epidemiology, Harvard School of Public Health
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Hofman, Albert
- Other Affiliation: Department of Epidemiology, Erasmus Medical Center
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Lunetta, Kathryn L
- Other Affiliation: Framingham Heart Study, The National Heart Lung and Blood Institute
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Palmieri, Giuseppe
- Other Affiliation: Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche
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Porcu, Eleonora
- Other Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche
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Rivadeneira, Fernando
- Other Affiliation: Department of Epidemiology, Erasmus Medical Center
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Rose, Lynda M
- Other Affiliation: Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School
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Splansky, Greta L
- Other Affiliation: Framingham Heart Study, The National Heart Lung and Blood Institute
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Stolk, Lisette
- Other Affiliation: Department of Internal Medicine, Erasmus Medical Center
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Uitterlinden, André G
- Other Affiliation: Department of Epidemiology, Erasmus Medical Center
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Chanock, Stephen J
- Other Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
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Crisponi, Laura
- Other Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche
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Demerath, Ellen W
- Other Affiliation: Division of Epidemiology and Community Health, University of Minnesota
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Murabito, Joanne M
- Other Affiliation: Framingham Heart Study, The National Heart Lung and Blood Institute
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Ridker, Paul M
- Other Affiliation: Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School
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Stricker, Bruno H
- Other Affiliation: Department of Epidemiology, Erasmus Medical Center
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Hunter, David J
- Other Affiliation: Department of Epidemiology, Harvard School of Public Health
- Abstract
- Introduction A younger age at menarche and an older age at menopause are well established risk factors for breast cancer. Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown. Methods In this study, we investigated 19 and 17 newly identified single nucleotide polymorphisms (SNPs) from the ReproGen Consortium that have been associated with age at menarche and age at natural menopause, respectively, and assessed their associations with breast cancer risk in 6 population-based studies among up to 3,683 breast cancer cases and 34,174 controls in white women of European ancestry. In addition, we used these SNPs to calculate genetic risk scores (GRSs) based on their associations with each trait. Results After adjusting for age and potential population stratification, two age at menarche associated SNPs (rs1079866 and rs7821178) and one age at natural menopause associated SNP (rs2517388) were associated with breast cancer risk (p values, 0.003, 0.009 and 0.023, respectively). The odds ratios for breast cancer corresponding to per-risk-allele were 1.14 (95% CI, 1.05 to 1.24), 1.08 (95% CI, 1.02 to 1.15) and 1.10 (95% CI, 1.01 to 1.20), respectively, and were in the direction predicted by their associations with age at menarche or age at natural menopause. These associations did not appear to be attenuated by further controlling for self-reported age at menarche, age at natural menopause, or known breast cancer susceptibility loci. Although we did not observe a statistically significant association between any GRS for reproductive aging and breast cancer risk, the 4th and 5th highest quintiles of the younger age at menarche GRS had odds ratios of 1.14 (95% CI, 1.01 to 1.28) and 1.13 (95% CI, 1.00 to 1.27), respectively, compared to the lowest quintile. Conclusions Our study suggests that three genetic variants, independent of their associations with age at menarche or age at natural menopause, were associated with breast cancer risk and may contribute modestly to breast cancer risk prediction; however, the combination of the 19 age at menarche or the 17 age at natural menopause associated SNPs did not appear to be useful for identifying a high risk subgroup for breast cancer.
- Date of publication
- March 20, 2012
- DOI
- Identifier
- 22433456
- https://doi.org/10.1186/bcr3155
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Chunyan He et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Breast Cancer Research
- Journal volume
- 14
- Journal issue
- 2
- Page start
- R54
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1465-5411
- Bibliographic citation
- Breast Cancer Research. 2012 Mar 20;14(2):R54
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- January 20, 2017
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