CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?
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Althoff, Keri N, et al. Cd4 Count At Presentation for Hiv Care In the United States and Canada: Are Those Over 50 Years More Likely to Have a Delayed Presentation?. BioMed Central Ltd, 2010. https://doi.org/10.17615/nr1r-9s63APA
Althoff, K., Gebo, K., Gange, S., Klein, M., Brooks, J., Hogg, R., Bosch, R., Horberg, M., Saag, M., Kitahata, M., Eron, J., Napravnik, S., Rourke, S., Gill, M., Rodriguez, B., Sterling, T., Deeks, S., Martin, J., Jacobson, L., Kirk, G., Collier, A., Benson, C., Silverberg, M., Goedert, J., Mc Kaig, R., Thorne, J., Rachlis, A., Moore, R., & Justice, A. (2010). CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?. BioMed Central Ltd. https://doi.org/10.17615/nr1r-9s63Chicago
Althoff, Keri N., Kelly A Gebo, Stephen J Gange, Marina B Klein, John T Brooks, Robert S Hogg, Ronald J Bosch et al. 2010. Cd4 Count At Presentation for Hiv Care In the United States and Canada: Are Those Over 50 Years More Likely to Have a Delayed Presentation?. BioMed Central Ltd. https://doi.org/10.17615/nr1r-9s63- Creator
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Althoff, Keri N.
- Other Affiliation: Johns Hopkins Bloomberg School of Public Health
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Gebo, Kelly A.
- Other Affiliation: Johns Hopkins University School of Medicine
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Gange, Stephen J.
- Other Affiliation: Johns Hopkins Bloomberg School of Public Health
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Klein, Marina B.
- Other Affiliation: McGill University
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Brooks, John T.
- Other Affiliation: Centers for Disease Control and Prevention
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Hogg, Robert S.
- Other Affiliation: Simon Fraser University
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Bosch, Ronald J.
- Other Affiliation: Harvard University
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Horberg, Michael A.
- Other Affiliation: Kaiser Permanente Northern California
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Saag, Michael S.
- Other Affiliation: University of Alabama at Birmingham
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Kitahata, Mari M.
- Other Affiliation: University of Washington
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Eron, Joseph
- Affiliation: School of Medicine, Department of Medicine
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Napravnik, Sonia
- Affiliation: School of Medicine, Department of Medicine
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Rourke, Sean B.
- Other Affiliation: University of Toronto
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Gill, M. John
- Other Affiliation: University of Calgary
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Rodriguez, Benigno
- Other Affiliation: Case Western Reserve University
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Sterling, Timothy R.
- Other Affiliation: Vanderbilt University
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Deeks, Steven G.
- Other Affiliation: University of California San Francisco
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Martin, Jeffrey N.
- Other Affiliation: University of California San Francisco
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Jacobson, Lisa P.
- Other Affiliation: Johns Hopkins Bloomberg School of Public Health
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Kirk, Gregory D.
- Other Affiliation: Johns Hopkins Bloomberg School of Public Health
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Collier, Ann C.
- Other Affiliation: University of Washington
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Benson, Constance A.
- Other Affiliation: University of California San Diego
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Silverberg, Michael J.
- Other Affiliation: Kaiser Permanente Northern California
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Goedert, James J.
- Other Affiliation: National Institutes of Health
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McKaig, Rosemary G.
- Other Affiliation: National Institutes of Health
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Thorne, Jennifer
- Other Affiliation: Johns Hopkins University School of Medicine
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Rachlis, Anita
- Other Affiliation: University of Toronto
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Moore, Richard D.
- Other Affiliation: Johns Hopkins University School of Medicine
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Justice, Amy C.
- Other Affiliation: Yale University School of Medicine
- Abstract
- We assessed CD4 count at initial presentation for HIV care among ≥50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to <50-year-olds. 44,491 HIV-infected individuals in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) were included in our study. Trends in mean CD4 count (measured as cells/mm3) and 95% confidence intervals ([,]) were determined using linear regression stratified by age category and adjusted for gender, race/ethnicity, HIV transmission risk and cohort. From 1997-2007, the proportion of individuals presenting for HIV care who were ≥50-years-old increased from 17% to 27% (p-value < 0.01). The median CD4 count among ≥50 year-olds was consistently lower than younger adults. The interaction of age group and calendar year was significant (p-value <0.01) with both age groups experiencing modest annual improvements over time (< 50-year-olds: 5[4 , 6] cells/mm3; ≥50-year-olds: 7[5 , 9] cells/mm3), after adjusting for sex, race/ethnicity, HIV transmission risk group and cohort; however, increases in the two groups were similar after 2000. A greater proportion of older individuals had an AIDS-defining diagnosis at, or within three months prior to, first presentation for HIV care compared to younger individuals (13% vs. 10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed.
- Date of publication
- December 15, 2010
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Keri N Althoff et al.; licensee BioMed Central Ltd.
- Journal title
- AIDS Research and Therapy
- Journal volume
- 7
- Journal issue
- 1
- Page start
- 45
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1742-6405
- Bibliographic citation
- AIDS Research and Therapy. 2010 Dec 15;7(1):45
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- August 23, 2012
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