Nonspecific orofacial symptoms as risk factors for first-onset TMD and chronic TMD
Public Deposited- Last Modified
- February 26, 2019
- Creator
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Sun, Jenny
- Affiliation: Gillings School of Global Public Health, Department of Biostatistics
- Abstract
- Previous studies found the count of 6 nonspecific orofacial symptoms was one of the most important predictors of first-onset TMD. We further examined the influence of these symptoms (jaw siftness, cramping, fatigue, pressure, soreness, and ache) on first-onset TMD and chronic TMD among U.S. adults aged 18 to 44 years in the OPPERA study. We identified 259 first-onset TMD cases and 185 chronic TMD cases. Hazard ratios were computed to estimate the association between each nonspecific orofacial symptom and first-onset TMD. We calculated odds ratios to measure the association between each symptom and chronic TMD. A principal component analysis was used to determine if all six symptoms are measures of a single underlying construct or largely independent of one another. Multivariable cox models quantified the combined effects of non-specific orofacial symptoms, clinical orofacial measures, and first-onset TMD. Multivariable logistic models examined these same associations on chronic TMD. Each nonspecific orofacial symptom was significantly associated with increased incidence of first-onset TMD and greater odds of chronic TMD. Results from the principal component analysis suggest it is reasonable to summarize the six variables by simply counting the number of symptoms reported. In the multivariable analysis, nonspecific orofacial symptoms significantly predicted first-onset TMD (HR=1.33; 95% CI: 1.11-1.59) and chronic TMD (OR=3.06; 95% CI: 2.03-4.97). The results indicate that the count of nonspecific orofacial symptoms is an independent risk factor and not a surrogate variable for pain.
- Date of publication
- spring 2015
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- DOI
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- Rights statement
- In Copyright
- Note
- Funding: None
- Advisor
- Bair, Eric
- Degree
- Bachelor of Science in Public Health
- Honors level
- Highest Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 20
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