A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls
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Bartlett, David B, et al. A Novel Inflammatory Biomarker, Glyca, Associates with Disease Activity In Rheumatoid Arthritis and Cardio-metabolic Risk In Bmi-matched Controls. BioMed Central, 2016. https://doi.org/10.17615/8pza-6198APA
Bartlett, D., Connelly, M., Abou Assi, H., Bateman, L., Tune, K., Huebner, J., Kraus, V., Winegar, D., Otvos, J., Kraus, W., & Huffman, K. (2016). A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls. BioMed Central. https://doi.org/10.17615/8pza-6198Chicago
Bartlett, David B., Margery A Connelly, Hiba Abou Assi, Lori A Bateman, K. Noelle Tune, Janet L Huebner, Virginia B Kraus et al. 2016. A Novel Inflammatory Biomarker, Glyca, Associates with Disease Activity In Rheumatoid Arthritis and Cardio-Metabolic Risk In Bmi-Matched Controls. BioMed Central. https://doi.org/10.17615/8pza-6198- Creator
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Bartlett, David B.
- Other Affiliation: Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
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Connelly, Margery A.
- Other Affiliation: LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, USA
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AbouAssi, Hiba
- Other Affiliation: Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
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Bateman, Lori A.
- Affiliation: UNC Center for Health Promotion and Disease Prevention
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Tune, K. Noelle
- Affiliation: UNC Center for Health Promotion and Disease Prevention
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Huebner, Janet L.
- Other Affiliation: Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
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Kraus, Virginia B.
- Other Affiliation: Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
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Winegar, Deborah A.
- Other Affiliation: LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, USA
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Otvos, James D.
- Other Affiliation: LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, USA
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Kraus, William E.
- Other Affiliation: Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
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Huffman, Kim M.
- Other Affiliation: Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
- Abstract
- Abstract Background RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic risk in RA, and explore whether these relationships were similar to those for persons without RA. Methods Plasma GlycA was determined for 50 individuals with mild-moderate RA disease activity and 39 controls matched for age, gender, and body mass index (BMI). Regression analyses were performed to assess relationships between GlycA and important markers of traditional inflammation and cardio-metabolic health: inflammatory cytokines, disease activity, measures of adiposity and insulin resistance. Results On average, RA activity was low (DAS-28 = 3.0 ± 1.4). Traditional inflammatory markers, ESR, hsCRP, IL-1β, IL-6, IL-18 and TNF-α were greater in RA versus controls (P < 0.05 for all). GlycA concentrations were significantly elevated in RA versus controls (P = 0.036). In RA, greater GlycA associated with disease activity (DAS-28; RDAS-28 = 0.5) and inflammation (RESR = 0.7, RhsCRP = 0.7, RIL-6 = 0.3: P < 0.05 for all); in BMI-matched controls, these inflammatory associations were absent or weaker (hsCRP), but GlycA was related to IL-18 (RhsCRP = 0.3, RIL-18 = 0.4: P < 0.05). In RA, greater GlycA associated with more total abdominal adiposity and less muscle density (Rabdominal-adiposity = 0.3, Rmuscle-density = −0.3, P < 0.05 for both). In BMI-matched controls, GlycA associated with more cardio-metabolic markers: BMI, waist circumference, adiposity measures and insulin resistance (R = 0.3-0.6, P < 0.05 for all). Conclusions GlycA provides an integrated measure of inflammation with contributions from traditional inflammatory markers and cardio-metabolic sources, dominated by inflammatory markers in persons with RA and cardio-metabolic factors in those without.
- Date of publication
- April 12, 2016
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Bartlett et al.
- Language
- English
- Bibliographic citation
- Arthritis Research & Therapy. 2016 Apr 12;18(1):86
- Publisher
- BioMed Central
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