Do Obese Individuals Have Less Cross-Reactive, Non-Neutralizing Antibodies to the 2009 Pandemic H1N1 Influenza Virus?
Public Deposited- Last Modified
- February 26, 2019
- Creator
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Khan, Mahreed Rahman
- Affiliation: Gillings School of Global Public Health, Department of Nutrition
- Abstract
- Background: Obesity has recently become a major global health concern as the worldwide population of those who are obese has increased to over 1 billion overweight adults. Recent studies suggest that obesity is a risk factor for severity of influenza virus, especially during the 2009 pandemic H1N1 outbreak. During the 2009 influenza pandemic, it was found that while overall severity to pH1N1 was mild, obese individuals had higher rates of hospitalization and severity than healthy weight individuals. The mechanism for impaired immunity in obese individuals will be explored. Objective: To determine if naïve obese individuals have less pre-existing cross-reactive, non-neutralizing antibodies to pH1N1 proteins NP, M1 and HA than healthy weight individuals. Results: The average M1 antibody OD value in healthy weight patients was found to be 1.12 while average OD value in obese patients was found to be 1.01. The average NP antibody OD value in healthy weight patients was found to be 0.91 while the average antibody OD value in obese patients was found to be 0.97. The average HA antibody OD for healthy weight patients was 1.32 while the average antibody OD value for obese patients was 1.28. None of these differences were significant. Conclusion: Obese individuals had similar levels of pre-existing, non-neutralizing, cross-reactive antibodies to pH1N1 compared with healthy weight individuals. Mechanism for impaired immunity in obese individuals likely lies elsewhere.
- Date of publication
- spring 2014
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: None
- Advisor
- Beck, Melinda A.
- Degree
- Bachelor of Science in Public Health
- Honors level
- Highest Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 38
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