Collections > Electronic Theses and Dissertations > Are the GCF Levels of MCP-1 and RANTES Elevated in Peri-partum Women with Periodontitis as Compared to Healthy Controls?

The study objective was to compare levels of gingival crevicular fluid (GCF), MCP-1 and RANTES in peri-partum women with periodontal disease to healthy controls. This is secondary analysis of Oral Conditions and Pregnancy (OCAP), a case-control study. Subjects (N=80) were stratified post-hoc based on periodontal status. An oral exam was performed within 72 hours after delivery. Cases (n=42) had moderate to severe/periodontitis ([greater than or equal to] 15 sites with PD[greater than or equal to] 4mm). Controls (n=38) had a healthy periodontium (PD[less than or equal to] 3mm). Pregnancy history was obtained through charts and interviews. Statistical tests included chi-square and t-test. Groups were balanced for age (p=0.57) but not race. Cases and controls were 17% and 82% Caucasian, respectively (p<0 .0001). There were no statistically significant (SS) differences between cases and controls. MCP-1 and RANTES were lower in cases than controls although not SS. There is no significant difference between MCP-1 and RANTES levels in women with periodontitis compared with healthy controls. The study was supported by NIDCR grant RO-1-DE-12453.