Unexpected depletion in plasma choline and phosphatidylcholine concentrations in a pregnant woman with bipolar affective disorder being treated with lithuim, haloperidol and benztropine: a case report

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Creator
  • Gossell-Williams, Maxine
    • Other Affiliation: Department of Basic Medical Sciences, University of the West Indies, Jamaica
  • Fletcher, Horace
    • Other Affiliation: Department of Obstetrics, Gynaecology and Child Health, University of The West Indies, Jamaica
  • Zeisel, Steven H.
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
Abstract
  • Abstract Introduction Patients with bipolar affective disorder can be effectively managed with pharmacological intervention. This case report describes a pregnant woman with a ten-year history of bipolar affective disorder that was being treated with lithium, haloperidol and benztropine. Case presentation The patient had a normal pregnancy, but developed an elevated blood pressure and started to lose weight at 36 weeks of gestation. During pregnancy, plasma concentrations of choline and phosphatidylcholine are increased to meet the demands of the foetus. However, our findings in this case included depletion of plasma choline and phosphatidylcholine concentrations. Other unusual outcomes included low placental weight and low infant birth weight. Conclusion This report suggests that the pharmacological management of this patient could possibly account for the findings.
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  • Article
Rights statement
  • In Copyright
Rights holder
  • Maxine Gossell-Williams et al.; licensee BioMed Central Ltd.
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Journal title
  • Journal of Medical Case Reports
Journal volume
  • 2
Journal issue
  • 1
Page start
  • 55
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1752-1947
Bibliographic citation
  • Journal of Medical Case Reports. 2008 Feb 20;2(1):55
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • July 9, 2016

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