Parasite clearance following treatment with sulphadoxine-pyrimethamine for intermittent preventive treatment in Burkina-Faso and Mali: 42-day in vivo follow-up study
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Coulibaly, Sheick O, et al. Parasite Clearance Following Treatment with Sulphadoxine-pyrimethamine for Intermittent Preventive Treatment In Burkina-faso and Mali: 42-day In Vivo Follow-up Study. BioMed Central Ltd, 2014. https://doi.org/10.17615/v4m4-3s63APA
Coulibaly, S., Kayentao, K., Taylor, S., Guirou, E., Khairallah, C., Guindo, N., Djimde, M., Bationo, R., Soulama, A., Dabira, E., Barry, B., Niangaly, M., Diakite, H., Konate, S., Keita, M., Traore, B., Meshnick, S., Magnussen, P., Doumbo, O., & Ter Kuile, F. (2014). Parasite clearance following treatment with sulphadoxine-pyrimethamine for intermittent preventive treatment in Burkina-Faso and Mali: 42-day in vivo follow-up study. BioMed Central Ltd. https://doi.org/10.17615/v4m4-3s63Chicago
Coulibaly, Sheick O, Kassoum Kayentao, Steve Taylor, Etienne A Guirou, Carole Khairallah, Nouhoun Guindo, Moussa Djimde et al. 2014. Parasite Clearance Following Treatment with Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment In Burkina-Faso and Mali: 42-Day In Vivo Follow-Up Study. BioMed Central Ltd. https://doi.org/10.17615/v4m4-3s63- Creator
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Coulibaly, Sheick O
- Other Affiliation: Faculty of Health, University of Ouagadougou, Ouagadougou, Burkina Faso
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Kayentao, Kassoum
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali; Malaria Epidemiology Unit, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
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Taylor, Steve
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Division of Infectious Diseases & International Health Duke University Medical Center, Durham, NC, USA
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Guirou, Etienne A
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Khairallah, Carole
- Other Affiliation: Malaria Epidemiology Unit, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
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Guindo, Nouhoun
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Djimde, Moussa
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Bationo, Richard
- Other Affiliation: Faculty of Health, University of Ouagadougou, Ouagadougou, Burkina Faso
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Soulama, Alamissa
- Other Affiliation: Faculty of Health, University of Ouagadougou, Ouagadougou, Burkina Faso
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Dabira, Edgar
- Other Affiliation: Faculty of Health, University of Ouagadougou, Ouagadougou, Burkina Faso
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Barry, Binta
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Niangaly, Moussa
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Diakite, Hammadoun
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Konate, Sidiki
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Keita, Mohamed
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Traore, Boubacar
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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Meshnick, Steven R.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Magnussen, Pascal
- Other Affiliation: Centre for Medical Parasitology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Doumbo, Ogobara K
- Other Affiliation: Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine and Odonto-stomatology of Bamako, University of Sciences, Technics and Technologies, BP: 1805, Bamako, Mali
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ter Kuile, Feiko O
- Other Affiliation: Malaria Epidemiology Unit, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
- Abstract
- Abstract Background Intermittent Preventive Treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) is widely used for the control of malaria in pregnancy in Africa. The emergence of resistance to SP is a concern requiring monitoring the effectiveness of SP for IPTp. Methods This was an in-vivo efficacy study to determine the parasitological treatment response and the duration of post-treatment prophylaxis among asymptomatic pregnant women receiving SP as part of IPTp in Mali and Burkina-Faso. The primary outcome was the PCR-unadjusted % of patients with parasites recurrence by day 42 defined as a positive diagnostic test by malaria smear at any visit between days 4 and 42. Treatment failure was based on the standard World Health Organization criteria. The therapeutic response was estimated using the Kaplan-Meier curve. Results A total of 580 women were enrolled in Mali (N=268) and Burkina-Faso (N=312) and followed weekly for 42 days. Among these, 94.3% completed the follow-up. The PCR-unadjusted cumulative risk of recurrence by day 42 was 4.9% overall, and 3.2% and 6.5% in Mali and Burkina Faso respectively (Hazard Ratio [HR] =2.14, 95%, CI [0.93-4.90]; P=0.070), and higher among the primi– and secundigravida (6.4%) than multigravida (2.2%, HR=3.01 [1.04-8.69]; P=0.042). The PCR-adjusted failure risk was 1.1% overall (Mali 0.8%, Burkina-Faso 1.4%). The frequencies (95% CI) of the dhfr double and triple mutant and dhps 437 and 540 alleles mutant genotype at enrolment were 24.2% (23.7-25.0), 4.7% (4.4-5.0), and 21.4% (20.8-22.0) and 0.37% (0.29-0.44) in Mali, and 7.1% (6.5-7.7), 44.9% (43.8-46.0) and 75.3% (74.5-76.2) and 0% in Burkina-Faso, respectively. There were no dhfr 164L or dhps 581G mutations. Conclusion SP remains effective at clearing existing infections when provided as IPTp to asymptomatic pregnant women in Mali and Burkina. Continued monitoring of IPTp-SP effectiveness, including of the impact on birth parameters in this region is essential.
- Date of publication
- January 31, 2014
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Sheick O Coulibaly et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Malaria Journal
- Journal volume
- 13
- Journal issue
- 1
- Page start
- 41
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1475-2875
- Bibliographic citation
- Malaria Journal. 2014 Jan 31;13(1):41
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- August 26, 2015
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