A Systematic Approach for Identifying, Evaluating and Presenting Mechanistic Evidence in Human Health Risk Assessment
Public Deposited- Last Modified
- February 28, 2019
- Creator
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Kushman, Mary Elizabeth
- Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
- Abstract
- Clear documentation of literature search strategies and analysis methodologies can improve transparency in chemical hazard assessments. We sought to improve clarity for the scientific support for carcinogenic mechanism of action conclusions using a systematic approach to collection, selection, presentation, and evaluation of literature studies. We focused on how di(2-ethylhexyl)phthalate (DEHP) causes liver tumorigenesis, a question critical to interpreting a large and complex database of >3,000 peer-reviewed publications. Relevant mechanisms of hepatic carcinogenesis were identified from published reviews. The literature search strategy included relevant synonyms and wildcards for DEHP and metabolites, mechanisms, and species of interest. Tiered evaluation criteria for study exclusion/inclusion were defined, and applied to the retrieved literature. Manual curation was conducted for mechanisms with large literature databases. Literature trees documented identification, curation and selection of the literature evidence. The selected studies were summarized in evidence tables accompanied by succinct narratives. Primary publications were made available via the Health and Environmental Research Online (http://heroepagov/) database, and identified by evaluation criteria and key terms to permit organized retrieval. This approach effectively manages a large volume of literature, improves appraisal and synthesis of information, and enables analysis of similarity in mechanism of action across studies for the purpose of chemical hazard assessment.
- Date of publication
- November 2012
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- MacDonald Gibson, Jacqueline
- Guyton, Kathryn
- Rusyn, Ivan
- Degree
- Master of Public Health
- Academic concentration
- Environmental Health Sciences
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 2012
- Language
- Deposit record
- 5edc2a5d-0dd3-4d26-87fc-ca03080ac860
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