The Molecular Taxonomy of Primary Prostate Cancer
Public Deposited- Creator
-
Perou, Charles
- ORCID: https://orcid.org/0000-0001-9827-2247
- Affiliation: School of Medicine, Department of Genetics
- The Cancer Genome Atlas Research Network
- Abstract
- There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects.
- Date of publication
- 2015
- DOI
- Identifier
- 2-s2.0-84946195510
- https://doi.org/10.1016/j.cell.2015.10.025
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Cell
- Journal volume
- 163
- Journal issue
- 4
- Page start
- 1011
- Page end
- 1025
- Language
- English
- Version
- Postprint
- ISSN
- 0092-8674
Relations
- Parents:
This work has no parents.
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