Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study

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  • Ferreira, Isabel
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK
  • Croca, Sara
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK
  • Raimondo, Maria G
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK
  • Matharu, Manjit
    • Other Affiliation: Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
  • Miller, Sarah
    • Other Affiliation: Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
  • Giles, Ian
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK
  • Isenberg, David
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK; Arthritis Research UK Centre for Adolescent Rheumatology, UCL/UCLH/Great Ormond Street Hospital, London, UK
  • Ioannou, Yiannis
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK; Arthritis Research UK Centre for Adolescent Rheumatology, UCL/UCLH/Great Ormond Street Hospital, London, UK
  • Hanly, John G
    • Other Affiliation: Division of Rheumatology, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada
  • Urowitz, Murray B
    • Other Affiliation: Lupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
  • Anderson, Nicole
    • Other Affiliation: Lupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
  • Aranow, Cynthia
    • Other Affiliation: Feinstein Institute for Medical Research, Manhasset, NY, USA
  • Askanase, Anca
    • Other Affiliation: Rheumatology, Columbia University, New York, NY, USA
  • Bae, Sang-Cheol
    • Other Affiliation: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
  • Bernatsky, Sasha
    • Other Affiliation: Divisions of Clinical Epidemiology and Rheumatology, McGill University Health Centre, Montreal, QC, Canada
  • Bruce, Ian N
    • Other Affiliation: Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
  • Buyon, Jill
    • Other Affiliation: New York School of Medicine, New York, NY, USA
  • Clarke, Ann E
    • Other Affiliation: Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
  • Dooley, Mary A
    • Affiliation: School of Medicine, Thurston Arthritis Research Center
  • Fortin, Paul
    • Other Affiliation: Centre Hospitalier de l’Université Laval (CHUL), Québec, QC, Canada
  • Ginzler, Ellen
    • Other Affiliation: Downstate Medical Center Rheumatology, Brooklyn, New York, NY, USA
  • Gladman, Dafna
    • Other Affiliation: Lupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
  • Gordon, Caroline
    • Other Affiliation: Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
  • Inanc, Murat
    • Other Affiliation: Department of Internal Medicine, Istanbul University, Istanbul, Turkey
  • Jacobsen, Søren
    • Other Affiliation: Copenhagen Lupus and Vasculitis Clinic, Centre For Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark
  • Kalunian, Kenneth
    • Other Affiliation: University of California, San Diego, La Jolla, CA, USA
  • Kamen, Diane
    • Other Affiliation: Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA
  • Khamashta, Munther
    • Other Affiliation: FRCP Division of Women’s Health, King’s College, London, UK
  • Lim, Sam
    • Other Affiliation: Department of Medicine, Emory University, Atlanta, GA, USA
  • Manzi, Susan
    • Other Affiliation: Allegheny Health Network, Pittsburgh, PA, USA
  • Merrill, Joan
    • Other Affiliation: Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
  • Nived, Ola
    • Other Affiliation: Department of Rheumatology, Lund University, Lund, Sweden
  • Peschken, Christine
    • Other Affiliation: Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
  • Petri, Michelle
    • Other Affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Ramsey-Goldman, Rosalind
    • Other Affiliation: Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
  • Ruiz-Irastorza, Guillermo
    • Other Affiliation: Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute. Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
  • Sanchez-Guerrero, Jorge
    • Other Affiliation: Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada
  • Steinson, Kristjan
    • Other Affiliation: Department of Rheumatology, Landspitali University Hospital, Reykjavik, Iceland
  • Sturfelt, Gunnar K
    • Other Affiliation: Department of Rheumatology, Lund University, Lund, Sweden
  • van Vollenhoven, Ronald
    • Other Affiliation: Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Sweden
  • Wallace, Daniel J
    • Other Affiliation: Cedars-Sinai Medical Center/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
  • Zoma, Asad
    • Other Affiliation: Department of Rheumatology Hairmyres Hospital, East Kilbride, Scotland, UK
  • Rahman, Anisur
    • Other Affiliation: Centre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London WC1E 6JF, UK
Abstract
  • Abstract Background In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. Methods We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event. Results Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety. Conclusions Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.
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  • English
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  • Arthritis Research & Therapy. 2017 Dec 22;19(1):287
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  • BioMed Central

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