Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study
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Ncayiyana, Jabulani R, et al. Prevalence of Latent Tuberculosis Infection and Predictive Factors In an Urban Informal Settlement In Johannesburg, South Africa: a Cross-sectional Study. BioMed Central, 2016. https://doi.org/10.17615/w2z3-0n94APA
Ncayiyana, J., Bassett, J., West, N., Westreich, D., Musenge, E., Emch, M., Pettifor, A., Hanrahan, C., Schwartz, S., Sanne, I., & Van Rie, A. (2016). Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study. BioMed Central. https://doi.org/10.17615/w2z3-0n94Chicago
Ncayiyana, Jabulani R, Jean Bassett, Nora West, Daniel Westreich, Eustasius Musenge, Michael Emch, Audrey Pettifor et al. 2016. Prevalence of Latent Tuberculosis Infection and Predictive Factors In an Urban Informal Settlement In Johannesburg, South Africa: a Cross-Sectional Study. BioMed Central. https://doi.org/10.17615/w2z3-0n94- Creator
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Ncayiyana, Jabulani R
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 29 Princess of Wales Terrace, Johannesburg 2193, South Africa
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Bassett, Jean
- Other Affiliation: Witkoppen Health and Welfare Centre, 105 William Nicol Drive, Fourways, Johannesburg 2055, South Africa
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West, Nora
- Other Affiliation: Witkoppen Health and Welfare Centre, 105 William Nicol Drive, Fourways, Johannesburg 2055, South Africa
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Westreich, Daniel
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Musenge, Eustasius
- Other Affiliation: Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 29 Princess of Wales Terrace, Johannesburg 2193, South Africa
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Emch, Michael
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Pettifor, Audrey
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Hanrahan, Colleen F
- Other Affiliation: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA
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Schwartz, Sheree R
- Other Affiliation: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA
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Sanne, Ian
- Other Affiliation: Clinical HIV Research Unit, Department of Medicine, University of the Witwatersrand, Perth Road, Auckland Park, Johannesburg 2092, South Africa
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van Rie, Annelies
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Department of Epidemiology and Social Medicine, Faculty of Medicine and Health Sciences, University of Antwerp, Campus Drie Eiken, University Square, Wilrijk, Antwerp 2610, Belgium
- Abstract
- Abstract Background South Africa has one of the highest burdens of latent tuberculosis infection (LTBI) in high-risk populations such as young children, adolescents, household contacts of TB cases, people living with HIV, gold miners and health care workers, but little is known about the burden of LTBI in its general population. Methods Using a community-based survey with random sampling, we examined the burden of LTBI in an urban township of Johannesburg and investigated factors associated with LTBI. The outcome of LTBI was based on TST positivity, with a TST considered positive if the induration was ≥5 mm in people living with HIV or ≥10 mm in those with unknown or HIV negative status. We used bivariate and multivariable logistic regression to identify factors associated with LTBI Results The overall prevalence of LTBI was 34.3 (95 % CI 30.0, 38.8 %), the annual risk of infection among children age 0–14 years was 3.1 % (95 % CI 2.1, 5.2). LTBI was not associated with HIV status. In multivariable logistic regression analysis, LTBI was associated with age (OR = 1.03 for every year increase in age, 95 % CI = 1.01–1.05), male gender (OR = 2.70, 95 % CI = 1.55–4.70), marital status (OR = 2.00, 95 % CI = 1.31–3.54), and higher socio-economic status (OR = 2.11, 95 % CI = 1.04–4.31). Conclusions The prevalence of LTBI and the annual risk of infection with M. tuberculosis is high in urban populations, especially in men, but independent of HIV infection status. This study suggests that LTBI may be associated with higher SES, in contrast to the well-established association between TB disease and poverty.
- Date of publication
- November 8, 2016
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- The Author(s).
- Language
- English
- Bibliographic citation
- BMC Infectious Diseases. 2016 Nov 08;16(1):661
- Publisher
- BioMed Central
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