Global Health as an international development field has seen great accomplishments throughout the proceeding century. For this century, new challenges have arisen such as HIV/AIDS, globalization, and health disparities; so too must our responses change. This paper will deal with Leadership and its need to adapt to the problems at hand. Because of the complex and interdependent nature of the current global health challenges a new form of leadership will be required. I will explore throughout this work the response that future leaders should take while examining the implications of a holistic health framework.