Protective variant associated with alcohol dependence in a Mexican American cohort

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  • Norden-Krichmar, Trina M
    • Other Affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla CA, USA
  • Gizer, Ian R
    • Other Affiliation: Department of Psychological Sciences, University of Missouri, Columbia, USA
  • Wilhelmsen, Kirk
    • Affiliation: School of Medicine, Department of Genetics
  • Schork, Nicholas J
    • Other Affiliation: Department of Human Biology, J. Craig Venter Institute, USA
  • Ehlers, Cindy L
    • Other Affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La JollaCA, USA
Abstract
  • Background Mexican Americans, particularly those born in the United States, are at greater risk for alcohol associated morbidity and mortality. The present study sought to investigate whether specific genetic variants may be associated with alcohol use disorder phenotypes in a select population of Mexican American young adults. Methods The study evaluated a cohort of 427 (age 18 – 30 years) Mexican American men (n = 171) and women (n = 256). Information on alcohol dependence was obtained through interview using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). For all subjects, DNA was extracted from blood samples, followed by genotyping using an Affymetrix Axiom Exome1A chip. Results A protective variant (rs991316) located downstream from the ADH7 (alcohol dehydrogenase 7) gene showed suggestive significance in association with alcohol dependence symptom counts derived from DSM-III-R and DSM-IV criteria, as well as to clustered alcohol dependence symptoms. Additional linkage analysis suggested that nearby variants in linkage disequilibrium with rs991316 were not responsible for the observed association with the alcohol dependence phenotypes in this study. Conclusions ADH7 has been shown to have a protective role against alcohol dependence in previous studies involving other ethnicities, but has not been reported for Mexican Americans. These results suggest that variants near ADH7 may play a role in protection from alcohol dependence in this Mexican American cohort.
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  • Article
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  • In Copyright
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  • Norden-Krichmar et al.; licensee BioMed Central.
Journal title
  • BMC Medical Genetics
Journal volume
  • 15
Journal issue
  • 1
Page start
  • 136
Language
  • English
Bibliographic citation
  • BMC Medical Genetics. 2014 Dec 21;15(1):136
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  • BioMed Central

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