Complementary feeding: a Global Network cluster randomized controlled trial
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Krebs, Nancy F, et al. Complementary Feeding: a Global Network Cluster Randomized Controlled Trial. BioMed Central Ltd, 2011. https://doi.org/10.17615/q3x3-g308APA
Krebs, N., Hambidge, K., Mazariegos, M., Westcott, J., Goco, N., Wright, L., Koso Thomas, M., Tshefu, A., Bose, C., Pasha, O., Goldenberg, R., Chomba, E., Carlo, W., Kindem, M., Das, A., Hartwell, T., & Mc Clure, E. (2011). Complementary feeding: a Global Network cluster randomized controlled trial. BioMed Central Ltd. https://doi.org/10.17615/q3x3-g308Chicago
Krebs, Nancy F, K Michael Hambidge, Manolo Mazariegos, Jamie Westcott, Norman Goco, Linda L Wright, Marion Koso Thomas et al. 2011. Complementary Feeding: a Global Network Cluster Randomized Controlled Trial. BioMed Central Ltd. https://doi.org/10.17615/q3x3-g308- Creator
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Krebs, Nancy F
- Other Affiliation: University of Colorado Denver, Aurora, CO, USA
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Hambidge, K Michael
- Other Affiliation: University of Colorado Denver, Aurora, CO, USA
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Mazariegos, Manolo
- Other Affiliation: San Carlos University, Guatemala City, Guatemala
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Westcott, Jamie
- Other Affiliation: University of Colorado Denver, Aurora, CO, USA
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Goco, Norman
- Other Affiliation: RTI International, Research Triangle Park, NC, USA
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Wright, Linda L
- Other Affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA
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Koso-Thomas, Marion
- Other Affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA
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Tshefu, Antoinette
- Other Affiliation: Kinshasa School of Public Health, Kinshasa, Democratic Republic of Congo
- Bose, Carl
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Pasha, Omrana
- Other Affiliation: Aga Khan University, Karachi, Pakistan
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Goldenberg, Robert
- Other Affiliation: Drexel University College of Medicine, Philadelphia, PA, USA
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Chomba, Elwyn
- Other Affiliation: University Teaching Hospital, Lusaka, Zambia
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Carlo, Waldemar
- Other Affiliation: University of Alabama, Birmingham, AL, USA
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Kindem, Mark
- Other Affiliation: RTI International, Research Triangle Park, NC, USA
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Das, Abhik
- Other Affiliation: RTI International, Research Triangle Park, NC, USA
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Hartwell, Ty
- Other Affiliation: RTI International, Research Triangle Park, NC, USA
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McClure, Elizabeth
- Other Affiliation: RTI International, Research Triangle Park, NC, USA
- Abstract
- Abstract Background Inadequate and inappropriate complementary feeding are major factors contributing to excess morbidity and mortality in young children in low resource settings. Animal source foods in particular are cited as essential to achieve micronutrient requirements. The efficacy of the recommendation for regular meat consumption, however, has not been systematically evaluated. Methods/Design A cluster randomized efficacy trial was designed to test the hypothesis that 12 months of daily intake of beef added as a complementary food would result in greater linear growth velocity than a micronutrient fortified equi-caloric rice-soy cereal supplement. The study is being conducted in 4 sites of the Global Network for Women's and Children's Health Research located in Guatemala, Pakistan, Democratic Republic of the Congo (DRC) and Zambia in communities with toddler stunting rates of at least 20%. Five clusters per country were randomized to each of the food arms, with 30 infants in each cluster. The daily meat or cereal supplement was delivered to the home by community coordinators, starting when the infants were 6 months of age and continuing through 18 months. All participating mothers received nutrition education messages to enhance complementary feeding practices delivered by study coordinators and through posters at the local health center. Outcome measures, obtained at 6, 9, 12, and 18 months by a separate assessment team, included anthropometry; dietary variety and diversity scores; biomarkers of iron, zinc and Vitamin B12 status (18 months); neurocognitive development (12 and 18 months); and incidence of infectious morbidity throughout the trial. The trial was supervised by a trial steering committee, and an independent data monitoring committee provided oversight for the safety and conduct of the trial. Discussion Findings from this trial will test the efficacy of daily intake of meat commencing at age 6 months and, if beneficial, will provide a strong rationale for global efforts to enhance local supplies of meat as a complementary food for young children. Trial registration NCT01084109
- Date of publication
- January 13, 2011
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Nancy F Krebs et al.; licensee BioMed Central Ltd.
- License
- Journal title
- BMC Pediatrics
- Journal volume
- 11
- Journal issue
- 1
- Page start
- 4
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1471-2431
- Bibliographic citation
- BMC Pediatrics. 2011 Jan 13;11(1):4
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- July 16, 2016
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