Physical activity and FTO genotype by physical activity interactive influences on obesity

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  • Kim, Joon Y
    • Other Affiliation: Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, USA
  • DeMenna, Jacob T
    • Other Affiliation: College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, Phoenix, USA
  • Puppala, Sobha
    • Other Affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, USA
  • Chittoor, Geetha
    • Affiliation: Nutrition Research Institute, Gillings School of Global Public Health, Department of Nutrition
  • Schneider, Jennifer
    • Other Affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, USA
  • Duggirala, Ravindranath
    • Other Affiliation: South Texas Diabetes and Obesity Institute Edinburg Regional Academic Health Center University of Texas Health Science Center at San Antonio, San Antonio, USA
  • Mandarino, Lawrence J
    • Other Affiliation: College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, Phoenix, USA; Mayo/ASU Center for Metabolic and Vascular Biology, Phoenix, USA
  • Shaibi, Gabriel Q
    • Other Affiliation: Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, USA; Mayo/ASU Center for Metabolic and Vascular Biology, Phoenix, USA; College of Nursing & Health Innovation, Arizona State University, Phoenix, USA
  • Coletta, Dawn K
    • Other Affiliation: College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, Phoenix, USA; Mayo/ASU Center for Metabolic and Vascular Biology, Phoenix, USA
Abstract
  • Abstract Background Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA influences and interactive effects between FTO variants and PA on measures of adiposity in Latinos. Results After controlling for age and sex, participants who did not engage in regular PA exhibited higher BMI, fat mass, HC, and WC with statistical significance (P < 0.001). Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations. However, several of such interactive influences exhibited considerable trend towards association. Conclusions These data suggest that adiposity measures are associated with PA and FTO variants in Latinos, but the impact of their interactive influences on these obesity measures appear to be minimal. Future studies with large sample sizes may help to determine whether individuals with specific FTO variants exhibit differential responses to PA interventions.
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  • Article
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  • In Copyright
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  • Kim et al.
Language
  • English
Bibliographic citation
  • BMC Genetics. 2016 Feb 24;17(1):47
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  • BioMed Central

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