The purpose of this study was to evaluate the effects of pomegranate extract (PE) on anaerobic exercise and flow mediated dilation (FMD). In a randomized, crossover design, nineteen participants completed repeated sprint ability (RSA) tests and repetitions to fatigue (RTF) on bench press and leg press with consumption of PE or placebo. Brachial artery FMD was assessed by ultrasound to determine blood flow and vessel diameter. FMD was assessed at baseline, 30min post ingestion, immediately post exercise (IPost), and 30min post exercise (30minPostEx). With PE, blood flow significantly increased IPost RSA (mean difference [MD]=18.49 mL·min-1; p=0.05), and IPost and 30minPostEx RTF (p<0.05). Vessel diameter increased significantly 30minPostEx of RSA, and IPost and 30minPostEx RTF (p<0.05). With PE, power output increased significantly halfway (sprint 5 of 10) through the RSA (MD=31.81 Watts; p=0.046). Supplementation of PE augmented vessel diameter, blood flow and power, supporting ergogenic effects and enhanced vasodilation.