Chronic HPA Axis Response to Stress in Temporomandibular Disorder

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  • March 22, 2019
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  • Lambert, Cynthia A.
    • Affiliation: School of Dentistry, Division of Allied Dental Education, Dental Hygiene Master's Program
Abstract
  • Perceived stress is associated with temporomandibular disorder (TMD). We hypothesized that cortisol concentration, a biomarker of hypothalamic-pituitary-adrenal (HPA) axis function, was elevated in TMD cases relative to controls, and that perceived stress was positively correlated with cortisol concentration. In this case control study, TMD case status was determined by TMD Research Diagnostic Criteria. Adult participants (n=116) aged 18-59 years were recruited from within a 50-mile radius of the UNC at Chapel Hill. Cases (n=45) and controls (n=71) completed the 14-item Perceived Stress Scale using a reference interval of the past three months. Approximately 100 strands of hair were cut from the posterior vertex segment of their scalp and the most proximal portion was analyzed for cortisol concentration. TMD cases perceived higher stress than controls. Hair cortisol concentration was lower in TMD cases than controls. A weak negative relationship was determined between perceived stress and hair cortisol concentration.
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  • ... in partial fulfillment of the requirements for the degree of Master of Science in Dental Hygiene Education in the Department of Dental Ecology, School of Dentistry
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  • Sanders, Anne
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