Collections > Electronic Theses and Dissertations > Immunohistochemical evaluation of sex steroid hormones in sicca syndrome patients

Sjogren syndrome (SS) is a chronic autoimmune disease affecting mainly climacteric females. The coincidence of sex hormones decline and higher prevalence of SS in this population implies that such hormones participate in its pathogenesis. Their exact role in the pathogenesis of SS is still controversial. This study investigates the presence and location of sex hormone receptors within minor labial salivary glands (MLSG) in a cohort of sicca syndrome patients being evaluated for SS. An immunohistochemical comparison of the ratio of estrogen receptors (ER) to androgen receptors (AR) expression was correlated to the patients' focus score (FS). A greater intensity of androgen receptor expression in SS patients, especially in the nucleus of acinar cells was found when compared to the other receptors (p<0.001). However, no statistically significant difference was found in the ratio of ER to AR as a function of FS in our group of patients