The effects of sucrose abstinence on motivated responding and nucleus accumbens cellular signaling

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  • March 22, 2019
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  • Jones, Joshua Lacey
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
Abstract
  • A critical feature of cocaine addiction is the strong propensity to relapse following periods of abstinence. Here, we examined whether abstinence from sucrose self-administration in rats altered behavioral responding and nucleus accumbens (NAc) cell firing in a manner similar to that observed following cocaine abstinence. Rats were trained to self-administer sucrose, and then underwent either a 0, 7 or 30 day period of abstinence. Electrophysiological recording procedures were used to examine NAc activity during resumption of sucrose self-administration. Results showed no increase in sucrose-seeking or changes in cell firing of NAc neurons following any abstinence period. Furthermore, in a separate group of animals trained under identical conditions, motivated responding was assessed during extinction and cue-induced reinstatement tasks. No evidence was obtained for any alterations in sucrose-seeking across abstinence conditions. Taken together, these results provide insight about the neural circuitry of natural and drug rewards, and relapse behavior.
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  • In Copyright
Advisor
  • Carelli, Regina
Degree granting institution
  • University of North Carolina at Chapel Hill
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  • Open access
Date uploaded
  • October 19, 2010

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