Translocation and potential neurological effects of fine and ultrafine particles a critical update
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Peters, Annette, et al. Translocation and Potential Neurological Effects of Fine and Ultrafine Particles a Critical Update. BioMed Central Ltd, 2006. https://doi.org/10.17615/0cph-1s85APA
Peters, A., Veronesi, B., Calderón Garcidueñas, L., Gehr, P., Chen, L., Geiser, M., Reed, W., Rothen Rutishauser, B., Schürch, S., & Schulz, H. (2006). Translocation and potential neurological effects of fine and ultrafine particles a critical update. BioMed Central Ltd. https://doi.org/10.17615/0cph-1s85Chicago
Peters, Annette, Bellina Veronesi, Lilian Calderón Garcidueñas, Peter Gehr, Lung Chen, Marianne Geiser, William Reed et al. 2006. Translocation and Potential Neurological Effects of Fine and Ultrafine Particles a Critical Update. BioMed Central Ltd. https://doi.org/10.17615/0cph-1s85- Creator
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Peters, Annette
- Other Affiliation: Institute of Epidemiology; Focus Network of Aerosols and Health, GSF-National Research Center for Environment and Health, Neuherberg, Germany
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Veronesi, Bellina
- Other Affiliation: National Health and Environmental Effects Research Laboratory, Neurotoxicology Division, US Environmental Protection Agency, RTP, NC, USA
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Calderón-Garcidueñas, Lilian
- Other Affiliation: Instituto Nacional de Pediatría, Mexico City 14410, Mexico; The Center for Structural and Functional Neurosciences, University of Montana, Missoula, MT 59812, USA
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Gehr, Peter
- Other Affiliation: Institute of Anatomy, University of Bern, 3012 Bern, Switzerland
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Chen, Lung
- Other Affiliation: New York University School of Medicine, Department of Environmental Medicine, Tuxedo, NY, USA
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Geiser, Marianne
- Other Affiliation: Institute of Anatomy, University of Bern, 3012 Bern, Switzerland
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Reed, William
- Affiliation: School of Medicine, Department of Pediatrics, Center for Environmental Medicine, Asthma and Lung Biology
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Rothen-Rutishauser, Barbara
- Other Affiliation: Institute of Anatomy, University of Bern, 3012 Bern, Switzerland
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Schürch, Samuel
- Other Affiliation: Institute of Anatomy, University of Bern, 3012 Bern, Switzerland; Department of Physiology and Biophysics, University of Calgary, Canada
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Schulz, Holger
- Other Affiliation: Focus Network of Aerosols and Health; Institute for Inhalation Biology, GSF-National Research Center for Environment and Health, Neuherberg, Germany
- Abstract
- Abstract Particulate air pollution has been associated with respiratory and cardiovascular disease. Evidence for cardiovascular and neurodegenerative effects of ambient particles was reviewed as part of a workshop. The purpose of this critical update is to summarize the evidence presented for the mechanisms involved in the translocation of particles from the lung to other organs and to highlight the potential of particles to cause neurodegenerative effects. Fine and ultrafine particles, after deposition on the surfactant film at the air-liquid interface, are displaced by surface forces exerted on them by surfactant film and may then interact with primary target cells upon this displacement. Ultrafine and fine particles can then penetrate through the different tissue compartments of the lungs and eventually reach the capillaries and circulating cells or constituents, e.g. erythrocytes. These particles are then translocated by the circulation to other organs including the liver, the spleen, the kidneys, the heart and the brain, where they may be deposited. It remains to be shown by which mechanisms ultrafine particles penetrate through pulmonary tissue and enter capillaries. In addition to translocation of ultrafine particles through the tissue, fine and coarse particles may be phagocytized by macrophages and dendritic cells which may carry the particles to lymph nodes in the lung or to those closely associated with the lungs. There is the potential for neurodegenerative consequence of particle entry to the brain. Histological evidence of neurodegeneration has been reported in both canine and human brains exposed to high ambient PM levels, suggesting the potential for neurotoxic consequences of PM-CNS entry. PM mediated damage may be caused by the oxidative stress pathway. Thus, oxidative stress due to nutrition, age, genetics among others may increase the susceptibility for neurodegenerative diseases. The relationship between PM exposure and CNS degeneration can also be detected under controlled experimental conditions. Transgenic mice (Apo E -/-), known to have high base line levels of oxidative stress, were exposed by inhalation to well characterized, concentrated ambient air pollution. Morphometric analysis of the CNS indicated unequivocally that the brain is a critical target for PM exposure and implicated oxidative stress as a predisposing factor that links PM exposure and susceptibility to neurodegeneration. Together, these data present evidence for potential translocation of ambient particles on organs distant from the lung and the neurodegenerative consequences of exposure to air pollutants.
- Date of publication
- September 8, 2006
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Annette Peters et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Particle and Fibre Toxicology
- Journal volume
- 3
- Journal issue
- 1
- Page start
- 13
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1743-8977
- Bibliographic citation
- Particle and Fibre Toxicology. 2006 Sep 08;3(1):13
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- November 6, 2015
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