Objectives: To compare two methods of measuring mandibular asymmetry. The first method uses mirroring of the mandible in the midsagittal plane; the second uses arbitrary mirroring of the mandible and registration on the cranial base. Methods: Surface models were constructed from CBCT scans of 50 patients with asymmetry. For the first approach, a midsagittal plane was defined for each patient as the plane passing through Nasion, ANS, and Basion. Mirrors for both halves of the mandible were created. The second approach was to mirror each model on an arbitrary plane. Both original and arbitrarily mirrored images were registered on the cranial base. Surface distances between hemimandibles and mirrors were calculated for nine regions. Results: There was no statistically significant difference between the mean surface distance measurements obtained with the two approaches, and comparing both halves in most areas. Conclusion: Both mirroring techniques provided similarquantification of mandibular asymmetry in this cohort.