Efforts towards the total synthesis of (+)-sorangicin A

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  • March 20, 2019
Creator
  • Haley, Matthew W.
    • Affiliation: College of Arts and Sciences, Department of Chemistry
Abstract
  • Efforts towards (+)-sorangicin A, a previously unprepared antibiotic macrolide, are reported. A modular approach which investigates several coupling strategies for the union of three core cyclic ether fragments was utilized. The bicyclic ether and tetrahydropyran moieties were constructed utilizing a ringclosing/epoxide opening strategy while the dihydropyran subunit relied on a ring-closing metathesis for the formation of the heterocycle. The three core synthetic fragments were elaborated to various synthetic intermediates and several coupling strategies were evaluated.
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  • In Copyright
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  • Crimmins, Michael T.
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  • Open access
Date uploaded
  • October 11, 2010

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