Demonstrated Transfection Using DNA and a Polymer with Low Cytotoxicity for Gene Therapies
Public Deposited- Last Modified
- May 6, 2020
- Creator
-
Collins, Graham Calvin
- Affiliation: Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics
- Abstract
- The usefulness of gene therapies is largely dependent on the transfection efficiency of the therapy. Since gene therapy can treat some types of cancer, infectious diseases like AIDS, and several neurodegenerative diseases, there is a great need for effective carriers. Many carriers have been developed which can, to varying extents, deliver genes to several cell types. However, gene size limits, sustained expression, particle size, and net complex charge make delivery of therapies challenging. Transfection efficiency, or the ability to deliver chosen nucleic acids to cells and produce modified cells, must be maximized while minimizing immune response and damage to the host for a therapy to be clinically relevant.
- Date of publication
- spring 2017
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: Gump Family Undergraduate Research Fund
- Advisor
- Ainslie, Kristy
- Degree
- Bachelor of Science
- Academic concentration
- Biomedical Engineering
- Honors level
- Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 2017
- Language
- English
Relations
- Parents:
This work has no parents.
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