Workers who handle small animals in a research laboratory are exposed to many risk factors which, if not addressed, can lead to work related musculoskeletal disorders (WMSDs ). Little data have been published that address the awkward postures, force, and repetition to which these workers are constantly exposed while providing care to maintain healthy animal colonies. This paper outlines a program for identifying and correcting ergonomic deficiencies and instituting prevention strategies. A guideline is provided for developing an interdisciplinary ergonomics team with occupational and environmental health nurses taking the lead, and the roles of other members of this team identified. A successful ergonomics program will lead to fewer work related musculoskeletal disorders and a healthier work force.