This dissertation focuses on transformations in border-based economic zones in the Greater Mekong Subregion (GMS). The political and economic processes building border economies in the GMS over the past 10-20 years shed light on the politics of scale and the ways in which states do and do not seek to link territories and citizens with the political dynamics, economic systems, labor and natural resources of neighboring countries. Mechanisms of global economic management, regulation and control are a fragile, eclectic mixture. Governance networks comprising state practices, labor regimes, globalized production networks and multilateral agencies are creating spaces for capital accumulation in the borderlands of the GMS. I find that no one actor can independently configure and maintain the geo-economic and geo-political re-ordering taking place in the GMS. This is largely due to the fact that space making is never only about locking in capital, but also about shaping a range of political desires through spatial reconfigurations that offer new opportunities for profit and power. From this perspective space is multiple and contingent, and global and situated elements combine to create new forms of spatial administration to control feminized and migrant labor. The different forms these take along the GMS borderlands offers insight into changing global-local governance structures and practices.