The development of novel polyesters as unique biomaterials
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Brosnan, Sarah Mae. The Development of Novel Polyesters As Unique Biomaterials. University of North Carolina at Chapel Hill, 2012. https://doi.org/10.17615/2neh-s863APA
Brosnan, S. (2012). The development of novel polyesters as unique biomaterials. University of North Carolina at Chapel Hill. https://doi.org/10.17615/2neh-s863Chicago
Brosnan, Sarah Mae. 2012. The Development of Novel Polyesters As Unique Biomaterials. University of North Carolina at Chapel Hill. https://doi.org/10.17615/2neh-s863- Last Modified
- March 22, 2019
- Creator
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Brosnan, Sarah Mae
- Affiliation: College of Arts and Sciences, Department of Chemistry
- Abstract
- This thesis describes the development of unique biomaterials, particularly radiopaque and shape memory polyester materials. Specifically, the first developed examples of a functionalizable shape memory polymer, monodisperse shape memory polymer particles, and highly iodinated processable iodinated materials are discussed herein. Materials with dynamically controllable surface chemistry and topography are highly desirable. Here, a functionalizable shape memory system has been designed that has uniquely remote-controllable functionality and geometry. This was accomplished by incorporating controlled amounts of an azide-containing monomer into a shape memory polymeric material. These materials are capable of physically changing their surface geometry over a range of length scales. Using copper assisted click chemistry, different surfaces are made. Materials with these combined features can change their presented geometry and functionality at tunable transition temperatures. Micro- and nanosized particles capable of changing size and shape on command remain elusive. This work presents the first method that uses thermal shape memory to create particles of specific sizes and shapes that can shape shift on demand. Particles are fabricated with an initial shape, force is applied to the particle to lock in a temporary shape, and the initial shape is returned by heating above the melting temperature. This unique method allows for particles that have a variety of starting and temporary shapes, return to their original shape at a tunable temperature, and possess tunable surface chemistry. Computed tomography is an essential tool for the everyday diagnosis of numerous diseases and conditions, but it traditionally relies on contrast agents that are liquid in nature; thus, they lack specificity and exhibit rapid extravasation. Here, iodinated polyesters have been developed that show high radiopacity, low cytotoxicity, low cost, and high processablity. By using wholly aliphatic iodinated polyesters, the polymer properties are easily tuned to produce a multitude of materials with different thermal and mechanical properties. These iodinated polyesters can then be endcapped with a photo-curable methacrylate group, which allows easy processing of the material into films or particles. Additionally, radiopaque biomaterials such as implants, components of implants, and radiopaque glues can be realized with the developed material.
- Date of publication
- December 2012
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- In Copyright
- Advisor
- Ashby, Valerie
- Degree
- Doctor of Philosophy
- Graduation year
- 2012
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