Gaps in Butadiene Biomarkers of Exposure and Effect

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Last Modified
  • March 21, 2019
Creator
  • Carro-Mojica, Sujey
    • Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
Abstract
  • 1,3-Butadiene (BD) is a well-characterized carcinogen that is both an occupational and an environmental hazard. BD is metabolized mainly by CYP4502E1 into epoxides, 1,2-epoxybutene (EB), 1,2:3,4-diepoxybutane (DEB) and 3,4-epoxy-1,2-butanediol (EB-diol). These reactive epoxides can react with and form adducts with both hemoglobin (Hb) and DNA. Tumor formation in rodents shows species and gender differences, with mice being much more sensitive than rats, and female mice being more sensitive than male mice. The weight of evidence presented across rodent species suggests there are sex specific differences in BD-DNA crosslinks, tumor formation, and mutagenicity and supports the hypothesis that DNA repair processes rather than differences in BD metabolism drive tumor formation in a sex dependent manner. Combining metabolic biomarkers data with tumor formation presented interspecies differences that were difficult to understand. Some of the questions that remained unclear were how BD was acting as a carcinogen, how we could use this data, and what these findings meant for human risk assessment. To help answer these questions, we looked at BD metabolic activation in male and female mice, rats and humans and BD-epoxide induced DNA repair.
Date of publication
Keyword
DOI
Resource type
Rights statement
  • In Copyright
Advisor
  • Ball, Louise
  • Gold, Avram
  • Swenberg, James
  • Bodnar, Wanda
  • Nakamura, Jun
  • Walker, Vernon
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2018
Language

Relations

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details CarroMojica_unc_0153D_14643.pdf 2019-04-12 Public Download