The potential for selective pharmacological therapies through biased receptor signaling
Public Deposited- Creator
-
Kenakin, Terrance
- Affiliation: School of Medicine, Department of Pharmacology
- Abstract
- Abstract The discovery that not all agonists uniformly activate cellular signaling pathways (biased signaling) has greatly changed the drug discovery process for agonists and the strategy for treatment of disease with agonists. Technological advances have enabled complex receptor behaviors to be viewed independently and through these assays, the bias for an agonist can be quantified. It is predicted that therapeutic phenotypes will be linked, through translational studies, to quantified scales of bias to guide medicinal chemists in the drug discovery process.
- Date of publication
- August 13, 2012
- DOI
- Identifier
- doi:10.1186/2050-6511-13-3
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Terry Kenakin et al.; licensee BioMed Central Ltd.
- License
- Journal title
- BMC Pharmacology and Toxicology
- Journal volume
- 13
- Journal issue
- 1
- Page start
- 3
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 2050-6511
- Bibliographic citation
- BMC Pharmacology and Toxicology. 2012 Aug 13;13(1):3
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- July 16, 2016
Relations
- Parents:
This work has no parents.
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