Antibody Response to the Influenza Virus Over Time as it Relates to Varying Metabolic States
Public Deposited- Last Modified
- April 30, 2020
- Creator
-
Rezk, Omar
- Affiliation: Gillings School of Global Public Health, Department of Nutrition
- Abstract
- In previous studies, the antibody response to the trivalent influenza vaccine at 30 days and 12 months post vaccination was analyzed. Subjects were vaccinated between Sept- Oct, and as the peak of the flu season is usually somewhere between December and March10, a mid-point between 30 days and one year post vaccination would be important to test. It is also important to consider the metabolic profiles of the subjects and whether metformin use can influence the antibody response. Therefore, we initiated an experiment into the investigation of the effect of time and metabolic state (diabetic or non-diabetic) on the humoral and cell mediated immune responses to the A/California/7/2009 (H1N1) pdm09-like virus. We hypothesized that treatment of metformin may normalize the metabolism of the immune cells, therefore their antibody responses may be higher compared with obese people not treated with metformin.
- Date of publication
- spring 2017
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: Beck Lab
- Advisor
- Beck, Melinda A.
- Degree
- Bachelor of Science in Public Health
- Academic concentration
- Nutrition
- Honors level
- Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 2017
- Language
- English
Relations
- Parents:
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