Collaborative Cross recombinant inbred inter-crosses (RIX) for the study of the behavioral and structural consequences of chronic antipsychotic treatment
Public Deposited- Last Modified
- February 27, 2019
- Creator
-
DeCristo, Daniela
- Affiliation: College of Arts and Sciences, Department of Biology
- Abstract
- Schizophrenia is an idiopathic disorder that affects approximately 1% of the global population, and presents with persistent delusions, hallucinations, and disorganized behaviors. Antipsychotics are the standard treatment of schizophrenia, but are frequently discontinued by patients due to inefficacy and/or intolerable side effects. Chronic treatment with the antipsychotic haloperidol causes tardive dyskinesia in about 30% of patients, manifested in humans as involuntary and often permanent orofacial movements. Tardive dyskinesia can be effectively modeled in rodents by means of vacuous chewing movements. Recombinant inbred inter-crossed (RIX) mice, derived from the genetically diverse Collaborative Cross murine population, were treated with haloperidol and subjected to a panel of behavioral assessments to monitor the development of side effects. Furthermore, transition electron microscopy (TEM) was used to assess the impact of chronic haloperidol treatment on synaptic structures in wild-type C57BL/6 mice. While there were similar neuronal synaptic architectures in the corpus striata across treatment groups, distinctions were found in phenotypic behavior between strain genotypes. These findings add to our understanding of the genetic basis of the side effects of haloperidol with the aim of higher efficacy and lower burden of haloperidol treatment.
- Date of publication
- autumn 2015
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: None
- Advisor
- Evans, Mara
- Degree
- Bachelor of Science
- Honors level
- Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 28
Relations
- Parents:
This work has no parents.