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The association of spatial T wave axis deviation with incident coronary events. The ARIC cohort

Creators: Vaidean, Georgeta D, Rautaharju, Pentti M, Prineas, Ronald J, Whitsel, Eric A, Chambless, Lloyd E, Folsom, Aaron R, Rosamond, Wayne D, Zhang, Zhu-Ming, Crow, Richard S, Heiss, Gerardo

File Type: pdf | Filesize: 310.9 KB | Date Added: 2012-09-05 | Date Created: 2005-01-11

Abstract Background Although current evidence suggests that the spatial T wave axis captures important information about ventricular repolarization abnormalities, there are only a few and discordant epidemiologic studies addressing the ability of the spatial T wave axis to predict coronary heart disease (CHD) occurrence. Methods This prospective study analyzed data from 12,256 middle-aged African American and white men and women, from the Atherosclerosis Risk in Communities Study (ARIC). Following a standardized protocol, resting standard 12-lead, 10-second electrocardiograms were digitized and analyzed with the Marquette GE program. The median follow-up time was 12.1 years; incident coronary heart disease comprised fatal and non-fatal CHD events. Results The incidence rate of CHD was 4.26, 4.18, 4.28 and 5.62 per 1000 person-years respectively, across the spatial T wave axis quartiles. Among women for every 10 degrees increase in the spatial T wave axis deviation, there was an estimated increase in the risk of CHD of 1.16 (95% CI 1.04&#8211;1.28). After adjustment for age, height, weight, smoking, hypertension, diabetes, QRS axis and minor T wave abnormalities, this hazard rate ratio for women fell to 1.03 (0.92&#8211;1.14). The corresponding crude and adjusted hazard ratios for men were 1.05 (95% CI 0.96&#8211;1.15) and 0.95 (0.86&#8211;1.04) respectively. Conclusions In conclusion, this prospective, population-based, bi-ethnic study of men and women free of coronary heart disease at baseline shows that spatial T wave axis deviation is not associated with incident coronary events during long-term follow up. It is doubtful that spatial T wave axis deviation would add benefit in the prediction of CHD events above and beyond the current traditional risk factors.