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This study investigated the effects of combining exercise and recreation therapy as a comprehensive intervention to mitigate breast cancer treatment side effects. Fourteen post treated breast cancer patients were randomly assigned to either an exercise only (EX only) or exercise + recreation therapy (EX + RT) group. The EX only group participated in an individualized exercise prescription 3 days/week for eight weeks. The EX + RT group received the same exercise prescription plus an additional 30 minutes of recreation therapy (Biofeedback) 3 days/week for eight weeks. The results revealed no significant differences in the changes in VO2max or fatigue between the EX + RT and EX only groups. There was, however, a significant difference in the changes in quality of life (QOL) between groups (p=.009). This finding supports the benefits of combining exercise and recreation therapy as a well rounded intervention in the management of breast cancer patient QOL.