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The Relationship between Changes in Weight Status and Insulin Resistance in Youth

Creators: Ondrak, Kristin S, McMurray, Robert G, Battaglini, Claudio L, Evenson, Kelly, Harrell, Joanne S

File Type: pdf | Filesize: 551.8 KB | Date Added: 2012-08-23 | Date Created: 2009-04-16

This study examined changes in insulin resistance (IR) in 120 youth over two years. IR was quantified via homeostatic model (HOMA-IR), and weight status changes were quantified via body mass index (BMI). When all participants were considered, the mean HOMA-IR and BMI increased 13.4% and 1.65 units, respectively. Change in BMI z-score and percent change in HOMA-IR were moderately associated (). Follow-up analyses were performed for the following weight groups: NN (normal at baseline and two years later), NO (normal to overweight), ON (overweight to normal), and OO (overweight at both points). The NO group had a greater change in HOMA-IR (+50%) compared to other groups: ON (8%), NN (+2%), and OO (0.1%) (). The association between changes in BMI z-score and HOMA-IR was when only the NO and ON groups were included. These results reinforce the importance of preventing youth from becoming overweight to control IR.